利用基于噻吩的三联吡啶锌（Ⅱ）配合物的超分辨显微镜对活细胞中线粒体 DNA 的可视化。
Visualization of mitochondrial DNA in living cells with super-resolution microscopy using thiophene-based terpyridine Zn(ii) complexes.
机构信息
Department of Chemistry, Key Laboratory of Functional Inorganic Material Chemistry of Anhui Province, Anhui University, Hefei 230601, P. R. China.
出版信息
Chem Commun (Camb). 2018 Oct 4;54(80):11288-11291. doi: 10.1039/c8cc06276e.
We present a thiophene-based terpyridine Zn(ii) complex (namely LC) which could specifically target live cell mitochondria via binding with mitochondrial DNA (mtDNA). Due to its high biocompatibility, red emission and photo-stability, mtDNA distribution within mitochondrial cristae and inner matrix in living cells was successfully visualized using stimulated emission depletion (STED) nanoscopy with unprecedented resolution.
我们提出了一种基于噻吩的三联吡啶锌（II）配合物（即 LC），它可以通过与线粒体 DNA（mtDNA）结合，特异性靶向活细胞线粒体。由于其高生物相容性、红色发射和光稳定性，使用受激发射损耗（STED）纳米显微镜以空前的分辨率成功地可视化了活细胞中线粒体嵴和内部基质中的 mtDNA 分布。
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