非编码 RNA 在心血管衰老中的作用。

Noncoding RNAs in Cardiovascular Aging.

机构信息

Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.

Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

出版信息

Adv Exp Med Biol. 2018;1086:37-53. doi: 10.1007/978-981-13-1117-8_3.

DOI:10.1007/978-981-13-1117-8_3

PMID:30232751

Abstract

With a progressively growing elderly population, aging-associated cardiovascular diseases and other pathologies have brought great burden to the economy, society, and individuals. Therefore, identifying therapeutic targets and developing effective strategies to prevent from cardiovascular aging are highly needed. Accumulating evidences suggest that noncoding RNAs (ncRNAs) such as microRNAs and long noncoding RNAs (lncRNAs) play important roles in regulating gene expression, which contributes to many pathophysiological processes of cellular senescence, aging, and aging-related diseases in cardiovascular systems. Here we provided a general overview of ncRNAs as well as the underlying mechanisms involved in cardiovascular aging. Although the importance of ncRNAs in cardiovascular aging has been reported and commonly acknowledged, further studies are still necessary to elucidate the underlying molecular mechanisms.

摘要

随着老年人口的不断增长，与衰老相关的心血管疾病和其他病理给经济、社会和个人带来了巨大的负担。因此，确定治疗靶点和开发有效的策略来预防心血管衰老非常必要。越来越多的证据表明，非编码 RNA（ncRNA），如 microRNAs 和长非编码 RNA（lncRNA），在调节基因表达方面发挥着重要作用，这有助于心血管系统中细胞衰老、衰老和与衰老相关疾病的许多病理生理过程。在这里，我们提供了 ncRNA 的概述以及涉及心血管衰老的潜在机制。尽管 ncRNA 在心血管衰老中的重要性已经被报道并得到普遍认可，但仍需要进一步的研究来阐明其潜在的分子机制。