Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg.
Department of Medical Biology and Genetics, Maltepe University Faculty of Medicine, Istanbul, Turkey.
Ageing Res Rev. 2022 May;77:101610. doi: 10.1016/j.arr.2022.101610. Epub 2022 Mar 23.
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.
心血管疾病（CVDs）是全球成年人群发病率和死亡率的主要原因，也是严重的经济负担和公共卫生关注问题。大多数人类基因并不编码蛋白质。然而，非编码转录本在衰老中起着重要作用，大大增加了 CVD 的风险。非编码 RNA（ncRNA）是与衰老相关的多种生物学过程的关键调节剂，如氧化应激、线粒体功能障碍和慢性炎症。ncRNA 也参与心血管系统的病理生理发展，包括心律失常、心脏肥大、纤维化、心肌梗死和心力衰竭。在这篇综述文章中，我们介绍了 ncRNA 在心血管衰老和疾病中的作用及其在 CVD 中的潜在治疗应用。
