Perksanusak T, Panyakhamlerd K, Hirankarn N, Suwan A, Vasuratna A, Taechakraichana N
a Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
b Department of Microbiology, Faculty of Medicine , Chulalongkorn University , Bangkok , Thailand.
Climacteric. 2018 Dec;21(6):581-585. doi: 10.1080/13697137.2018.1507020. Epub 2018 Sep 20.
This study assessed the correlation of plasma microRNA-21 expression and bone turnover markers (BTMs: CTx, P1NP) in healthy Thai postmenopausal women. We secondarily compared microRNA-21 expression between participants with normal and low bone mineral density (BMD: osteopenia and osteoporosis).
Postmenopausal women who had never been diagnosed with fracture or never used anti-osteoporosis drugs were included in this study. Baseline characteristics were collected from all 195 participants. BTMs and plasma miR-21-5p were analyzed from blood collection at 8:00 and 9:00 am after overnight fasting for at least 8 h.
There was no significant correlation between miR-21-5p and any of the BTMs (CTx, r = 0.094, p = 0.19; P1NP, r = 0.05, p = 0.485). Significant correlation between miR-21-5p and P1NP was found when participants were further categorized into those aged ≥70 years (r = 0.46, p = 0.05) and those having osteoporosis (r = 0.51, p = 0.06). Slight negative correlations were found between miR-21-5p and BMD. There was statistically significant higher expression of miR-21-5p in those with low BMD when compared to the normal BMD group (p < 0.01).
In this study, we did not find significant correlation between plasma microRNA-21-5p expression and the BTMs. Nevertheless, there seemed to be higher expression of miR-21-5p in the low BMD participants.
本研究评估了泰国健康绝经后女性血浆微小RNA-21表达与骨转换标志物（BTMs：I型胶原交联C末端肽（CTx）、I型前胶原氨基端前肽（P1NP））之间的相关性。其次，我们比较了骨密度正常和偏低（BMD：骨质减少和骨质疏松）参与者之间微小RNA-21的表达情况。
本研究纳入了从未被诊断为骨折或从未使用过抗骨质疏松药物的绝经后女性。收集了所有195名参与者的基线特征。在至少禁食8小时后的上午8:00和9:00采集血液，分析BTMs和血浆miR-21-5p。
miR-21-5p与任何一种BTMs之间均无显著相关性（CTx，r = 0.094，p = 0.19；P1NP，r = 0.05，p = 0.485）。当参与者进一步分为年龄≥70岁的人群（r = 0.46，p = 0.05）和患有骨质疏松症的人群（r = 0.51，p = 0.06）时，发现miR-21-5p与P1NP之间存在显著相关性。miR-21-5p与骨密度之间存在轻微的负相关。与骨密度正常组相比，骨密度偏低者的miR-21-5p表达在统计学上显著更高（p < 0.01）。
在本研究中，我们未发现血浆微小RNA-21-5p表达与BTMs之间存在显著相关性。然而，骨密度偏低的参与者中miR-21-5p的表达似乎更高。
