Pandya Nischal R, Alphonso Nelson, Tu Quyen, Venugopal Prem, Schlapbach Luregn J
Pediatric Cardiac Surgery, Lady Cilento Children's Hospital, Brisbane, QLD, Australia.
Mater Research Institute, The University of Queensland, Brisbane, QLD, Australia.
Front Cardiovasc Med. 2018 Sep 4;5:121. doi: 10.3389/fcvm.2018.00121. eCollection 2018.
Prolonged postoperative vasoplegia is known to occur following cardiac surgery in patients on chronic angiotensin II receptor blocker (ARB) treatment in adults. The perioperative management of these drugs in the pediatric population is not well described and here we would like to highlight this fact. While ARBs are increasingly used in children and adolescents with hypertension, there is lack of data to guide optimal pre-surgical management in the pediatric age group. We report two cases of prolonged vasoplegia following cardiopulmonary bypass occurring in adolescent patients on chronic ARB therapy and the importance of cessation of these drugs preoperatively.
已知在接受慢性血管紧张素 II 受体阻滞剂（ARB）治疗的成年患者进行心脏手术后会出现术后持续性血管麻痹。这些药物在儿科患者围手术期的管理尚无充分描述，在此我们想强调这一事实。虽然 ARB 在患有高血压的儿童和青少年中使用越来越多，但缺乏数据来指导该年龄组的最佳术前管理。我们报告了两例在接受慢性 ARB 治疗的青少年患者体外循环后出现持续性血管麻痹的病例，以及术前停用这些药物的重要性。
