选定生物标志物在主动脉瓣反流中的应用价值。
The usefulness of selected biomarkers in aortic regurgitation.
机构信息
Department of Acquired Cardiac Defects, Institute of Cardiology, Alpejska 42, Warsaw, Poland.
Department of Cardiosurgery and Transplantology, Institute of Cardiology, Warsaw, Poland.
出版信息
Cardiol J. 2019;26(5):477-482. doi: 10.5603/CJ.a2018.0108. Epub 2018 Sep 20.
BACKGROUND
The aim of the study was to investigate the prognostic value of selected biomarkers in patients with aortic regurgitation undergoing valve surgery.
METHODS
A prospective study was conducted on a group of consecutive patients with hemodynamically significant aortic regurgitation that underwent elective aortic valve surgery. The primary endpoint was 30-day mortality and any major adverse event within 30 days.
RESULTS
The study group included 205 consecutive patients who underwent replacement or repair of the aortic valve. The primary endpoint occurred in 72 patients. At multivariate analysis red cell distribution width (RDW; p = 0.03) and high-sensitivity troponin T (hs-TnT; p = 0.02) remained independent predictors of the major complications including death.
CONCLUSIONS
Elevated preoperative RDW and hs-TnT were associated with a poorer outcome following aortic valve surgery.
背景
本研究旨在探讨接受瓣膜手术的主动脉瓣反流患者中选择的生物标志物的预后价值。
方法
对一组接受主动脉瓣反流择期手术的连续患者进行前瞻性研究。主要终点为 30 天死亡率和 30 天内任何主要不良事件。
结果
研究组包括 205 例连续接受主动脉瓣置换或修复的患者。主要终点发生在 72 例患者中。多变量分析显示红细胞分布宽度（RDW；p = 0.03）和高敏肌钙蛋白 T（hs-TnT；p = 0.02）仍然是死亡等主要并发症的独立预测因素。
结论
术前 RDW 和 hs-TnT 升高与主动脉瓣手术后的不良预后相关。
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