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本文引用的文献

1
High-sensitivity troponin T is a prognostic marker of hemodynamic instability in patients undergoing valve surgery.高敏肌钙蛋白 T 是行瓣膜手术患者血流动力学不稳定的预后标志物。
Biomark Med. 2018 Dec;12(12):1303-1309. doi: 10.2217/bmm-2018-0186. Epub 2018 Dec 6.
2
The usefulness of selected biomarkers in aortic regurgitation.选定生物标志物在主动脉瓣反流中的应用价值。
Cardiol J. 2019;26(5):477-482. doi: 10.5603/CJ.a2018.0108. Epub 2018 Sep 20.
3
Red Cell Distribution Width as a Prognostic Marker in Patients Undergoing Valve Surgery.红细胞分布宽度作为瓣膜手术患者的预后标志物
J Heart Valve Dis. 2017 Nov;26(6):714-720.
4
Red cell distribution width as a predictor of multiple organ dysfunction syndrome in patients undergoing heart valve surgery.红细胞分布宽度作为心脏瓣膜手术患者多器官功能障碍综合征的预测指标
Biol Open. 2018 Oct 16;7(10):bio036251. doi: 10.1242/bio.036251.
5
Role of elevated red cell distribution width on acute kidney injury patients after cardiac surgery.红细胞分布宽度升高在心脏手术后急性肾损伤患者中的作用。
BMC Cardiovasc Disord. 2018 Aug 14;18(1):166. doi: 10.1186/s12872-018-0903-4.
6
Risk factors and short-term prognosis of preoperative renal insufficiency in infective endocarditis.感染性心内膜炎术前肾功能不全的危险因素及短期预后
J Thorac Dis. 2018 Jun;10(6):3679-3688. doi: 10.21037/jtd.2018.06.11.
7
National 10-year trends and outcomes of isolated and concomitant tricuspid valve surgery.孤立性及合并性三尖瓣手术的全国10年趋势及结果
J Cardiovasc Surg (Torino). 2019 Feb;60(1):119-127. doi: 10.23736/S0021-9509.18.10468-X. Epub 2018 Jul 3.
8
Perioperative Acute Kidney Injury: Prevention, Early Recognition, and Supportive Measures.围手术期急性肾损伤：预防、早期识别和支持措施。
Nephron. 2018;140(2):105-110. doi: 10.1159/000490500. Epub 2018 Jun 26.
9
Nitric Oxide Decreases Acute Kidney Injury and Stage 3 Chronic Kidney Disease after Cardiac Surgery.一氧化氮可降低心脏手术后急性肾损伤和 3 期慢性肾脏病的发生风险。
Am J Respir Crit Care Med. 2018 Nov 15;198(10):1279-1287. doi: 10.1164/rccm.201710-2150OC.
10
Number of erythrocytes as a prognostic marker in patients undergoing heart valve surgery.红细胞数量作为心脏瓣膜手术患者的预后标志物
Kardiol Pol. 2018;76(4):791-793. doi: 10.5603/KP.2018.0076.

大小不均预测行心脏瓣膜手术的患者术后需要肾脏替代治疗。

Anisocytosis predicts postoperative renal replacement therapy in patients undergoing heart valve surgery.

机构信息

Department of Acquired Cardiac Defects, Institute of Cardiology, Alpejska 42, Warsaw, Poland.

出版信息

Cardiol J. 2020;27(4):362-367. doi: 10.5603/CJ.a2019.0020. Epub 2019 Feb 25.

DOI:10.5603/CJ.a2019.0020
PMID:30799549
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8016011/
Abstract

BACKGROUND

Acute kidney injury (AKI) is one of the serious postoperative complications in patients undergoing heart valve surgery. The aim of the present study was to identify selected biomarkers to predict AKI requiring renal replacement.

METHODS

A prospective study was conducted on a group of 751 patients undergoing heart valve surgery. The data on risk factors, preoperative complete blood count, course of operations and postoperative period was assessed. The primary endpoint at the 30-day follow-up was postoperative AKI requiring renal replacement therapy. The secondary end-point was death from all causes in patients with postoperative AKI requiring renal replacement.

RESULTS

The primary endpoint occurred in 46 patients. At multivariate analysis: age, red cell distribution width (RDW) and C-reactive protein remained independent predictors of the primary endpoint. Hemoglobin and RDW were associated with an increased risk of death.

CONCLUSIONS

Elevated RDW is associated with a higher risk of postoperative AKI and death in patients with AKI.

摘要

背景

急性肾损伤（AKI）是心脏瓣膜手术后患者的严重术后并发症之一。本研究的目的是确定一些有预测价值的生物标志物，用于预测需要肾脏替代治疗的 AKI。

方法

对 751 例接受心脏瓣膜手术的患者进行了前瞻性研究。评估了危险因素、术前全血细胞计数、手术过程和术后期间的数据。术后 30 天的主要终点是需要肾脏替代治疗的术后 AKI。次要终点是术后 AKI 需要肾脏替代治疗的患者的全因死亡。

结果

主要终点发生在 46 例患者中。多变量分析显示：年龄、红细胞分布宽度（RDW）和 C 反应蛋白仍然是主要终点的独立预测因素。血红蛋白和 RDW 与死亡风险增加相关。

结论

在 AKI 患者中，升高的 RDW 与术后 AKI 和死亡的风险增加相关。