培哚普利对自发性高血压大鼠的全身及局部节前和节后交感神经抑制作用
Systemic and regional pre- and post-junctional sympathoinhibitory effect of perindopril in spontaneously hypertensive rats.
作者信息
Richer C, Doussau M P, Giudicelli J F
出版信息
J Hypertens Suppl. 1986 Oct;4(3):S513-6.
The interaction between converting enzyme inhibition and sympathetic system activity at systemic and regional (renal, mesenteric, hindlimb) levels was investigated in adult pithed spontaneously hypertensive rats (SHR) using perindopril (5 mg/kg orally every day for 8 days) and the pulsed Doppler technique. Perindopril induced a decrease in systolic blood pressure and in regional vascular resistance which was abolished by binephrectomy. In addition, the drug had a sympathoinhibitory effect on the systemic vasopressor and the regional vasoconstrictor responses to cirazoline, especially UK 14304, an effect which was kidney-dependent (abolished by binephrectomy) and postjunctional, and spinal cord stimulation, an effect which was kidney-independent and most likely prejunctional in its mechanism.
在成年去脑自发性高血压大鼠（SHR）中，使用培哚普利（每天口服5毫克/千克，共8天）和脉冲多普勒技术，研究了全身和局部（肾、肠系膜、后肢）水平上转换酶抑制与交感神经系统活动之间的相互作用。培哚普利可使收缩压和局部血管阻力降低，双侧肾切除可消除这种降低。此外，该药物对全身血管升压反应和局部对可乐唑啉（尤其是UK 14304）的血管收缩反应具有交感抑制作用，这种作用依赖于肾脏（双侧肾切除可消除）且发生在节后，对脊髓刺激的交感抑制作用不依赖于肾脏，其机制很可能发生在节前。
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