Department of Psychiatry, Academic Medical Center, University of Amsterdam, P.O. Box 22660, 1100 DD, Amsterdam, The Netherlands.
Jellinek-Arkin, P.O. Box 75848, 1070 AV, Amsterdam, The Netherlands.
Harm Reduct J. 2018 Sep 20;15(1):47. doi: 10.1186/s12954-018-0253-7.
Cannabis-smoking patients with a psychotic disorder have poorer disease outcomes than non-cannabis-smoking patients with poorest outcomes in patients smoking high-potency cannabis (HPC) containing high Δ9-tetrahydrocannabinol (THC) and low cannabidiol (CBD). Quitting cannabis smoking or substitution of HPC by cannabis variants containing less THC and/or more CBD may benefit these patients. The present study explores whether daily HPC-smoking patients with schizophrenia accept smoking such variants.
Twelve male patients were asked to smoke on six different occasions one joint: on two occasions, the cannabis they routinely smoke (HPC; not blind), and blind in random order; on two occasions, cannabis containing low THC and no CBD; and on two occasions, cannabis containing low THC and high CBD.
Both substitute variants were appreciated, but patients preferred the HPC they usually smoked. The effect of the low THC/high CBD variant was reported by 32% to be too short and by 36% to be not strong enough, whereas this was reported by 5% and 64%, respectively, for the low THC cannabis variant.
Based on these findings, a larger and longer study on the efficacy of cannabis substitution treatment in HPC-smoking patients with schizophrenia seems feasible and should be considered.
2014-005540-17NL . Registered 22 October 2014, 2014-005540-17NL 20141215 CTA.xml.
与不吸烟的精神病患者相比，吸食高浓度大麻（HPC）的精神病患者（HPC 中含有高浓度四氢大麻酚（THC）和低浓度大麻二酚（CBD））的预后更差。戒烟或用 THC 含量低和/或 CBD 含量高的大麻变体替代 HPC 可能对这些患者有益。本研究探讨了患有精神分裂症的每日 HPC 吸烟患者是否接受吸食此类变体。
要求 12 名男性患者在六个不同场合吸食一支大麻：两种情况是吸食他们通常吸食的大麻（HPC；非盲），并随机盲吸；两种情况是吸食 THC 含量低且不含 CBD 的大麻；还有两种情况是吸食 THC 含量低但 CBD 含量高的大麻。
两种替代变体都受到了赞赏，但患者更喜欢他们通常吸食的 HPC。32%的患者报告低 THC/高 CBD 变体的效果太短，36%的患者报告效果不够强，而低 THC 大麻变体的报告比例分别为 5%和 64%。
基于这些发现，对 HPC 吸烟的精神分裂症患者进行大麻替代治疗的疗效进行更大规模和更长时间的研究似乎是可行的，应该考虑进行。
2014-005540-17NL。2014 年 10 月 22 日注册，2014-005540-17NL 20141215 CTA.xml。
