State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
Biosens Bioelectron. 2018 Dec 30;122:1-7. doi: 10.1016/j.bios.2018.09.029. Epub 2018 Sep 8.
Molecular robot provides a promising way to receive response signals and make decisions with intelligent information processing at the molecule level. In this work, a molecular robot prototype based on a europium(III)-cyclen complex (EuL) was designed and assembled, consisting of multiplex sensing and information processing in a single system. By utilizing the Eu ion as a central processing unit (CPU) and terpyridine (Terpy) group as an arm of the molecular robot, multiplex detection function of this molecular robot can be accomplished in three test channels: the detection of Fe with UV-vis, Zn using photoluminescence, and Mn using magnetic resonance imaging. The optimized structures revealed that the transition metal ions bound by the arms of two EuL molecules formed a hexacoordination octahedral rigidity structure in the adducts. For the structure of L and EuL, three pyridine rings of Terpy unit were not in a plane, and they were fixed to form a plane when captured the transition metal ions during the formation of the adducts. In addition, three different modes of molecular logic devices (OR, INHIBIT, and YES) were established based on relevant signals in the multiplex detection channels. The sensing of metal ions in human urine using EuL was also carried out, and the result demonstrated the presence of good recoveries and high analytical precision. Such a molecular robot prototype is expected to be used in intelligent medical diagnostics and, in particular, information processing at molecular level.
分子机器人在分子水平上通过智能信息处理提供了接收响应信号和做出决策的有前途的方法。在这项工作中，设计并组装了一种基于铕（III）-环戊二烯配合物（EuL）的分子机器人原型，它由单个系统中的多重传感和信息处理组成。通过将 Eu 离子用作中央处理单元（CPU）和三吡啶基（Terpy）基团作为分子机器人的臂，该分子机器人可以在三个测试通道中完成多重检测功能：使用紫外可见法检测 Fe，使用荧光法检测 Zn，使用磁共振成像检测 Mn。优化后的结构表明，由两个 EuL 分子的臂结合的过渡金属离子在加合物中形成了六配位八面体刚性结构。对于 L 和 EuL 的结构，Terpy 单元的三个吡啶环不在一个平面上，并且当在加合物形成过程中捕获过渡金属离子时，它们被固定形成一个平面。此外，基于多重检测通道中的相关信号，建立了三种不同模式的分子逻辑器件（OR、INHIBIT 和 YES）。还对 EuL 对人尿液中金属离子的传感进行了研究，结果表明具有良好的回收率和高分析精度。这种分子机器人原型有望用于智能医疗诊断，特别是在分子水平上的信息处理。
