Sakabe T
Gan No Rinsho. 1986 Aug;32(10):1333-7.
Because of several different histological types of epithelium in the anal canal, various kinds of carcinomas such as adenocarcinoma, squamous carcinoma, cloacogenic carcinoma arise from this region, and carcinoma related to fistula in-ano is one of the characteristic malignancies. Though the fundamental treatment of anal carcinoma is rectal amputation, prophylactic gland dissection of inguinal lymph-node is not necessary except a case with definite metastasis. Numerous kinds of adjuvant chemotherapy to radical operation have been tried, however, selection of antitumor drugs, method of administration are not settled yet, and, at present, long term clinical effects are unknown.
由于肛管存在几种不同组织学类型的上皮，该区域可发生各种癌，如腺癌、鳞癌、泄殖腔源癌，而肛瘘相关性癌是一种特征性恶性肿瘤。尽管肛管癌的基本治疗方法是直肠切除术，但除有明确转移的病例外，腹股沟淋巴结预防性腺体清扫并无必要。已经尝试了多种针对根治性手术的辅助化疗，然而，抗肿瘤药物的选择、给药方法尚未确定，目前，长期临床疗效尚不清楚。
