Vautrin J
J Theor Biol. 1986 Jun 7;120(3):363-70. doi: 10.1016/s0022-5193(86)80207-7.
The regular spacing of peaks throughout the amplitude distribution of miniature end-plate potentials, quantal evoked end-plate potentials and quantal currents was demonstrated using autocorrelations and power density spectra calculated from the number of events in the successive bins of the histograms built by Matteson et al. (1979), Kriebel & Florey (1983) and Erxleben & Kriebel (1984). At the same mouse neuromuscular junction, the calculated interpeak was constant for evoked and spontaneous quantal releases, throughout sequential sampling and after change of bin size. The presence of regular peak intervals supports the hypothesis that quantal potentials are composed of potential subunits the size of the smallest subminiature potential. Challenging the hypothesis of an acetylcholine quantum composed of acetylcholine subunits, a postsynaptic origin of the subunit is proposed on the basis of the spatial arrangement in rows of the ACh receptors. The ACh-saturating patch evoked by a quantum release (Land et al., 1980, 1981) activates 10-20 rows of receptors, which is roughly the number of subunits composing a quantal event. Therefore the position of the ACh patch or the continuous variations in its size might cause stepwise variations in the total number of ACh receptors activated by an ACh quantum.
通过对马特森等人（1979年）、克里贝尔和弗洛里（1983年）以及埃尔克斯莱本和克里贝尔（1984年）构建的直方图连续区间内事件数量计算得到的自相关和功率密度谱，证明了在微小终板电位、量子诱发终板电位和量子电流的幅度分布中，峰值具有规则间距。在同一只小鼠的神经肌肉接头处，对于诱发和自发的量子释放，在连续采样过程中以及改变区间大小时，计算得到的峰间距离是恒定的。规则峰间距的存在支持了这样一种假说，即量子电位由最小亚微型电位大小的电位亚基组成。基于乙酰胆碱受体呈排状的空间排列，对由乙酰胆碱亚基组成乙酰胆碱量子的假说提出质疑，提出亚基起源于突触后。量子释放诱发的乙酰胆碱饱和斑（兰德等人，1980年、1981年）激活10 - 20排受体，这大致是构成一个量子事件的亚基数量。因此，乙酰胆碱斑的位置或其大小的连续变化可能导致乙酰胆碱量子激活的乙酰胆碱受体总数的逐步变化。
