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PG545治疗后小鼠体重和食物摄入量的数据集。

Dataset on mice body weights and food intake following treatment with PG545.

作者信息

Kinaneh Safa, Agbaria Mohammad, Abu-Saleh Niroz, Hamoud Shadi

机构信息

Department of Physiology, Rappaport Faculty of Medicine, Technion, Haifa, Israel.

Department of Internal Medicine A, Rambam Health Care Campus, Haifa, Israel.

出版信息

Data Brief. 2018 Sep 6;20:1305-1308. doi: 10.1016/j.dib.2018.08.179. eCollection 2018 Oct.

DOI:10.1016/j.dib.2018.08.179
PMID:30238043
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6143748/
Abstract

This data article contains analysis of data observed in E mice placed on high fat diet, and treated by intraperitoneal injections of either normal saline (control) or the heparanase inhibitor PG545, in two different doses. Mice body weights and food intake were measured weekly and analyzed data are presented in graphs. Data will be of value for further understanding the role of the enzyme heparanase in controlling food intake and body weight. For further interpretations, see please "Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E mice" (Muhammad et al. 2018).

摘要

本数据文章包含对高脂饮食的E小鼠的数据分析,这些小鼠通过腹腔注射两种不同剂量的生理盐水(对照)或乙酰肝素酶抑制剂PG545进行处理。每周测量小鼠体重和食物摄入量,并以图表形式呈现分析数据。这些数据对于进一步了解乙酰肝素酶在控制食物摄入量和体重方面的作用具有重要价值。如需进一步解读,请参阅《乙酰肝素酶抑制减轻E小鼠的动脉粥样硬化进展和肝脏脂肪变性》(穆罕默德等人,2018年)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e884/6143748/db8202d0d1e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e884/6143748/db8202d0d1e6/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e884/6143748/db8202d0d1e6/gr1.jpg

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1
Dataset on mice body weights and food intake following treatment with PG545.PG545治疗后小鼠体重和食物摄入量的数据集。
Data Brief. 2018 Sep 6;20:1305-1308. doi: 10.1016/j.dib.2018.08.179. eCollection 2018 Oct.
2
Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E mice.肝素酶抑制可减轻 E 小鼠动脉粥样硬化进展和肝脏脂肪变性。
Atherosclerosis. 2018 Sep;276:155-162. doi: 10.1016/j.atherosclerosis.2018.07.026. Epub 2018 Jul 24.
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Heparanase Inhibition Prevents Liver Steatosis in E Mice.乙酰肝素酶抑制可预防E小鼠的肝脂肪变性。
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The heparanase inhibitor PG545 is a potent anti-lymphoma drug: Mode of action.硫酸乙酰肝素酶抑制剂 PG545 是一种强效的抗淋巴瘤药物:作用机制。
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The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.乙酰肝素酶抑制剂PG545可减弱结肠癌的起始和生长,并与p21表达增加相关。
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本文引用的文献

1
Heparanase inhibition attenuates atherosclerosis progression and liver steatosis in E mice.肝素酶抑制可减轻 E 小鼠动脉粥样硬化进展和肝脏脂肪变性。
Atherosclerosis. 2018 Sep;276:155-162. doi: 10.1016/j.atherosclerosis.2018.07.026. Epub 2018 Jul 24.
2
Heparanase Inhibition Reduces Glucose Levels, Blood Pressure, and Oxidative Stress in Apolipoprotein E Knockout Mice.肝素酶抑制可降低载脂蛋白 E 敲除小鼠的血糖、血压和氧化应激。
Biomed Res Int. 2017;2017:7357495. doi: 10.1155/2017/7357495. Epub 2017 Oct 26.
3
PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models.
PG545,一种双重肝素酶和血管生成抑制剂,在临床前模型中诱导出强大的抗肿瘤和抗转移疗效。
Br J Cancer. 2011 Feb 15;104(4):635-42. doi: 10.1038/bjc.2011.11. Epub 2011 Feb 1.