Dipartimento di Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Ancona, Italy.
Genome Biol Evol. 2018 Oct 1;10(10):2709-2715. doi: 10.1093/gbe/evy206.
Vitellogenin (Vtg) is a glycolipophosphoprotein produced by oviparous and ovoviviparous species and is the precursor protein of the yolk, an essential nutrient reserve for embryonic development and early larval stages. Vtg is encoded by a family of paralog genes whose number varies in the different vertebrate lineages. Its evolution has been the subject of considerable analyses but it remains still unclear. In this work, microsyntenic and phylogenetic analyses were performed in order to increase our knowledge on the evolutionary history of this gene family in vertebrates. Our results support the hypothesis that the vitellogenin gene family is expanded from two genes both present at the beginning of vertebrate radiation through multiple independent duplication events occurred in the diverse lineages.
卵黄蛋白原 (Vtg) 是卵生和卵胎生物种产生的糖脂磷蛋白，是蛋黄的前体蛋白，是胚胎发育和早期幼虫阶段必不可少的营养储备。Vtg 由一个基因家族编码，其数量在不同的脊椎动物谱系中有所不同。它的进化一直是大量分析的主题，但仍然不清楚。在这项工作中，进行了微同线性和系统发育分析，以增加我们对脊椎动物中这个基因家族进化历史的了解。我们的结果支持这样的假设，即卵黄蛋白原基因家族是通过在不同的谱系中发生的多个独立复制事件从最初存在于脊椎动物辐射中的两个基因扩展而来的。
