Cahill J I, Goulden B E, Jolly R D
Neuropathol Appl Neurobiol. 1986 Sep-Oct;12(5):459-75. doi: 10.1111/j.1365-2990.1986.tb00054.x.
A detailed investigation of the neuropathology of a horse affected with stringhalt was performed. Qualitative and quantitative light and electron microscopy, and single teased fibre preparations of peripheral nerve demonstrated predominantly axonal degeneration, the stage of which was appropriate for the duration of clinical signs. There was selective involvement of large myelinated nerve fibres. A proximal to distal increase in the severity of pathological changes was present in the peripheral nerves. The long left recurrent laryngeal nerve was the most severely affected, followed in order by its right counterpart, the hindlimb and forelimb nerves. Neurogenic atrophy of muscles innervated by affected peripheral nerves also showed a distally graded increase in severity. No lesions were observed in the central nervous system. It was concluded that this disease should be classified as a distal axonopathy.
对一匹患有间歇性痉挛的马的神经病理学进行了详细研究。定性和定量的光学显微镜和电子显微镜检查，以及外周神经的单根 teased 纤维制备显示，主要为轴突退变，其阶段与临床症状持续时间相符。大的有髓神经纤维有选择性受累。外周神经中病理变化的严重程度从近端到远端增加。左侧喉返神经受影响最严重，其次是右侧喉返神经、后肢神经和前肢神经。受影响外周神经支配的肌肉的神经源性萎缩在严重程度上也显示出向远端分级增加。在中枢神经系统中未观察到病变。得出的结论是，这种疾病应归类为远端轴索性神经病。
