Center of Excellence in Genomic Medicine Research, King Abdulaziz University, P.O. Box 80216, Jeddah 21589, Saudi Arabia.
Int J Mol Sci. 2018 Sep 20;19(10):2850. doi: 10.3390/ijms19102850.
Metformin (MTF) is a natural compound derived from the legume . It is the first line antidiabetic drug for type 2 diabetes (T2D) treatment. One of its main antidiabetic effects results from the reduction of hepatic glucose release. First scientific evidence for the anticancer effects of MTF was found in animal research, published in 2001, and some years later a retrospective observational study provided evidence that linked MTF to reduced cancer risk in T2D patients. Its pleiotropic anticancer effects were studied in numerous in vitro and in vivo studies at the molecular and cellular level. Although the majority of these studies demonstrated that MTF is associated with certain anticancer properties, clinical studies and trials provided a mixed view on its beneficial anticancer effects. This review emphasizes the pleiotropic effects of MTF and recent progress made in MTF applications in basic, preclinical, and clinical cancer research.
二甲双胍（MTF）是一种天然化合物，来源于豆科植物。它是治疗 2 型糖尿病（T2D）的一线抗糖尿病药物。其主要的抗糖尿病作用之一是减少肝脏葡萄糖的释放。MTF 的抗癌作用的第一个科学证据是在 2001 年发表的动物研究中发现的，几年后，一项回顾性观察研究提供了证据，表明 MTF 与 T2D 患者的癌症风险降低有关。其在分子和细胞水平的多种体外和体内研究中表现出多种抗癌作用。尽管这些研究中的大多数表明 MTF 与某些抗癌特性相关，但临床研究和试验对其有益的抗癌作用提供了不同的看法。这篇综述强调了 MTF 的多效性作用以及 MTF 在基础、临床前和临床癌症研究中的应用的最新进展。
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