Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
Beatson Institute for Cancer Research and University of Glasgow, Glasgow, UK.
Mol Cell. 2018 Sep 20;71(6):882-895. doi: 10.1016/j.molcel.2018.08.008.
Age-associated changes to the mammalian DNA methylome are well documented and thought to promote diseases of aging, such as cancer. Recent studies have identified collections of individual methylation sites whose aggregate methylation status measures chronological age, referred to as the DNA methylation clock. DNA methylation may also have value as a biomarker of healthy versus unhealthy aging and disease risk; in other words, a biological clock. Here we consider the relationship between the chronological and biological clocks, their underlying mechanisms, potential consequences, and their utility as biomarkers and as targets for intervention to promote healthy aging and longevity.
哺乳动物 DNA 甲基化组随年龄变化的特征已得到充分证实,据认为这些变化会促进衰老相关疾病的发生,如癌症。最近的研究已经确定了个体甲基化位点的集合,其总甲基化状态可以衡量生物钟年龄,这些位点被称为 DNA 甲基化钟。DNA 甲基化也可能作为健康与不健康衰老和疾病风险的生物标志物具有价值;换句话说,就是生物时钟。在这里,我们考虑了生物钟和生物时钟之间的关系、它们的潜在机制、潜在后果,以及它们作为生物标志物和干预靶点以促进健康衰老和长寿的应用价值。