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DNA Methylation Clocks in Aging: Categories, Causes, and Consequences.
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2
A Statistical Framework to Identify Deviation from Time Linearity in Epigenetic Aging.
PLoS Comput Biol. 2016 Nov 11;12(11):e1005183. doi: 10.1371/journal.pcbi.1005183. eCollection 2016 Nov.
4
Many chronological aging clocks can be found throughout the epigenome: Implications for quantifying biological aging.
Aging Cell. 2021 Nov;20(11):e13492. doi: 10.1111/acel.13492. Epub 2021 Oct 16.
5
The use of DNA methylation clock in aging research.
Exp Biol Med (Maywood). 2021 Feb;246(4):436-446. doi: 10.1177/1535370220968802. Epub 2020 Nov 11.
6
Epigenetic age-predictor for mice based on three CpG sites.
Elife. 2018 Aug 24;7:e37462. doi: 10.7554/eLife.37462.
8
DNA Methylation as a Biomarker of Aging in Epidemiologic Studies.
Methods Mol Biol. 2018;1856:219-231. doi: 10.1007/978-1-4939-8751-1_12.
9
Aging of blood can be tracked by DNA methylation changes at just three CpG sites.
Genome Biol. 2014 Feb 3;15(2):R24. doi: 10.1186/gb-2014-15-2-r24.
10
DNA methylation and healthy human aging.
Aging Cell. 2015 Dec;14(6):924-32. doi: 10.1111/acel.12349. Epub 2015 Apr 25.

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Spatial joint profiling of DNA methylome and transcriptome in tissues.
Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09478-x.
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Exploring the uncharted role of cell senescence in rare diseases.
Orphanet J Rare Dis. 2025 Sep 1;20(1):465. doi: 10.1186/s13023-025-03778-1.
3
Is the concept of mammalian epigenetic clocks universal and applicable to invertebrates?
Front Genet. 2025 Aug 8;16:1633921. doi: 10.3389/fgene.2025.1633921. eCollection 2025.
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Estimating Polar Bear () Age Based on an Epigenetic DNA Methylation Clock.
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Exploring Epigenetic Ageing Using Direct Methylome Sequencing.
Epigenomes. 2025 Jul 14;9(3):25. doi: 10.3390/epigenomes9030025.
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Associations between epigenetic age and brain age in young people.
Sci Rep. 2025 Jul 22;15(1):26609. doi: 10.1038/s41598-025-11350-x.
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GABA receptor activation contributes to post-surgery cognitive impairments in mice by inducing hippocampal BDNF hypermethylation.
Ann Med. 2025 Dec;57(1):2536221. doi: 10.1080/07853890.2025.2536221. Epub 2025 Jul 22.
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Spatial joint profiling of DNA methylome and transcriptome in mammalian tissues.
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DNA methylation protects cancer cells against senescence.
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本文引用的文献

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Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency.
Cell Syst. 2018 Jul 25;7(1):63-76.e12. doi: 10.1016/j.cels.2018.06.012.
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Multi-tissue DNA methylation age: Molecular relationships and perspectives for advancing biomarker utility.
Ageing Res Rev. 2018 Aug;45:15-23. doi: 10.1016/j.arr.2018.04.005. Epub 2018 Apr 23.
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Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex.
Nat Commun. 2018 Apr 24;9(1):1616. doi: 10.1038/s41467-018-03676-0.
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An epigenetic biomarker of aging for lifespan and healthspan.
Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414.
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DNA methylation-based biomarkers and the epigenetic clock theory of ageing.
Nat Rev Genet. 2018 Jun;19(6):371-384. doi: 10.1038/s41576-018-0004-3.
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GWAS of epigenetic aging rates in blood reveals a critical role for TERT.
Nat Commun. 2018 Jan 26;9(1):387. doi: 10.1038/s41467-017-02697-5.
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DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis.
JCI Insight. 2018 Jan 25;3(2). doi: 10.1172/jci.insight.96685.
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Faster ticking rate of the epigenetic clock is associated with faster pubertal development in girls.
Epigenetics. 2018;13(1):85-94. doi: 10.1080/15592294.2017.1414127. Epub 2018 Feb 15.

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