Department of Environmental Health, Harvard T.H. Chan School of Public Health and MD-PhD Program, Harvard Medical School, Boston, MA, USA.
Department of Environmental Health and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Ageing Res Rev. 2018 Aug;45:15-23. doi: 10.1016/j.arr.2018.04.005. Epub 2018 Apr 23.
The multi-tissue DNA methylation estimator of chronological age (DNAm-age) has been associated with a wide range of exposures and health outcomes. Still, it is unclear how DNAm-age can have such broad relationships and how it can be best utilized as a biomarker. Understanding DNAm-age's molecular relationships is a promising approach to address this critical knowledge gap. In this review, we discuss the existing literature regarding DNAm-age's molecular relationships in six major categories: animal model systems, cancer processes, cellular aging processes, immune system processes, metabolic processes, and nucleic acid processes. We also present perspectives regarding the future of DNAm-age research, including the need to translate a greater number of ongoing research efforts to experimental and animal model systems.
多组织 DNA 甲基化估计的生物钟 (DNAm-age) 与广泛的暴露和健康结果有关。尽管如此，目前尚不清楚 DNAm-age 如何具有如此广泛的关系，以及如何将其作为生物标志物最佳利用。了解 DNAm-age 的分子关系是解决这一关键知识空白的有前途的方法。在这篇综述中，我们讨论了关于 DNAm-age 在六个主要类别中的分子关系的现有文献：动物模型系统、癌症过程、细胞衰老过程、免疫系统过程、代谢过程和核酸过程。我们还提出了关于 DNAm-age 研究未来的观点，包括需要将更多正在进行的研究工作转化为实验和动物模型系统。
