尼日利亚北部赞法拉州 C 群脑膜炎奈瑟菌克隆复合体 ST-10217 爆发。
Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria.
机构信息
World Health Organization, Collaborating Centre for New Vaccines Surveillance, Medical Research Council Unit The Gambia at London School of Hygiene & Tropical Medicine, Atlantic Boulevard, Fajara, PO Box 273, Banjul, The Gambia.
Nigeria Center for Disease Control, Abuja, Nigeria.
出版信息
Sci Rep. 2018 Sep 21;8(1):14194. doi: 10.1038/s41598-018-32475-2.
After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21 Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5-14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5-9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks.
在 MenAfriVac 成功推出后，尼日利亚接连爆发了由脑膜炎奈瑟菌血清群 C（NmC）引起的脑膜炎疫情。尼日利亚西北部的赞法拉州最近成为 21 世纪以来 NmC 爆发规模最大的疫情中心，2016 年 12 月至 2017 年 5 月期间报告了 7140 例疑似脑膜炎病例和 553 例死亡病例。总发病率为每 10 万人 155 例，5-14 岁儿童占疑似病例的 47%（3369/7140）。5-9 岁儿童的病死率（CFR）为 10%，是 30 岁以上成年人（5%）报告的两倍。NmC 和肺炎球菌分别占实验室确诊病例的 94%（172/184）和 5%（9/184）。测序的 NmC 属于 ST-10217 克隆复合体（CC）。所有血清型肺炎球菌均为 PCV10 血清型。NmC ST-10217 CC 疫情的出现威胁到了 MenAfriVac 带来的公共卫生成果，这需要采取紧急战略行动来应对脑膜炎疫情。
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