贝叶斯发病风险估计（BREMSO）与早期多发性硬化症患者的认知和身体残疾相关。
The Bayesian risk estimate at onset (BREMSO) correlates with cognitive and physical disability in patients with early multiple sclerosis.
机构信息
Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, PO Box: 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon.
Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, PO Box: 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon; Abu-Haidar Neuroscience Institute, American University of Beirut Medical Center, PO Box: 11-0236, Riad El Solh, Beirut 1107 2020, Lebanon.
出版信息
Mult Scler Relat Disord. 2018 Nov;26:96-102. doi: 10.1016/j.msard.2018.09.003. Epub 2018 Sep 13.
BACKGROUND
Prevention of long-term disability is the goal of therapeutic intervention in Relapsing Remitting MS (RRMS). The Bayesian Risk Estimate for MS at Onset (BREMSO) gives an individual risk score predicting disease evolution into Secondary Progressive MS (SPMS). We investigated whether BREMSO correlates with physical disability, cognitive dysfunction, and regional brain atrophy early in MS.
METHODS
One hundred RRMS patients with at least two years of follow-up were enrolled. BREMSO score as well as Symbol Digit Modalities Test (SDMT) and Multiple Sclerosis Severity Score (MSSS), Timed 25-Foot Walk Test (T25-FW) and 9-Hole Peg Test (9-HPT), were assessed. Intracranial volume (ICV), subcortical gray matter structures and corpus callosum (CC) were automatically segmented on MRI images and their volumes measured.
RESULTS
BREMSO score correlated negatively with SDMT at visit1 (β = -0.33, p = 0.019), visit2 (β = -0.34, p = 0.017) and visit3 (β = -0.34, p = 0.014), and positively with MSSS at visit1 (r = 0.38, p = 0.006), visit2 (r = 0.47, p < 0.0001) and visit3 (r = 0.42, p = 0.002), but not with T25-FW and 9-HPT. BREMSO negatively correlated with CC volume at baseline (p < 0.03). No correlations were found with ICV and subcortical gray matter.
CONCLUSIONS
BREMSO score at onset correlated with physical disability (MSSS), cognitive function (SDMT) and CC volume measurements in patients with early MS.
背景
预防长期残疾是治疗复发缓解型多发性硬化症（RRMS）的目标。多发性硬化症发病时的贝叶斯风险估计（BREMSO）提供了一个预测疾病向继发性进展型多发性硬化症（SPMS）演变的个体风险评分。我们研究了 BREMSO 是否与多发性硬化症早期的身体残疾、认知功能障碍和区域性脑萎缩有关。
方法
纳入了 100 名至少随访两年的 RRMS 患者。评估了 BREMSO 评分、符号数字模态测试（SDMT）、多发性硬化症严重程度评分（MSSS）、定时 25 英尺步行测试（T25-FW）和 9 孔钉测试（9-HPT）。在 MRI 图像上自动分割脑容量（ICV）、皮质下灰质结构和胼胝体（CC），并测量其体积。
结果
BREMSO 评分与就诊 1 时的 SDMT 呈负相关（β= -0.33，p= 0.019），就诊 2 时（β= -0.34，p= 0.017）和就诊 3 时（β= -0.34，p= 0.014），与就诊 1 时的 MSSS 呈正相关（r= 0.38，p= 0.006），就诊 2 时（r= 0.47，p<0.0001）和就诊 3 时（r= 0.42，p= 0.002），但与 T25-FW 和 9-HPT 无关。BREMSO 与基线时的 CC 体积呈负相关（p<0.03）。与 ICV 和皮质下灰质无相关性。
结论
多发性硬化症早期患者的 BREMSO 评分与身体残疾（MSSS）、认知功能（SDMT）和 CC 体积测量有关。
Zotero 插件