Department of Anatomy, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Kidney Int. 2018 Oct;94(4):652-655. doi: 10.1016/j.kint.2018.06.023.
Tamm-Horsfall protein (THP)/uromodulin, the most abundant urinary protein, is produced in the thick ascending limb of the loop of Henle. Besides immunological functions, it has regulatory impact on ion transport and volume regulation. It had been debated whether the distal convoluted tubule is a source for THP as well. Novel results suggest that in its early portions, THP synthesis affects adaptive plasticity of the epithelium, stabilizes calcium homeostasis, and activates the thiazide-sensitive Na,Cl-cotransporter.
Tamm-Horsfall 蛋白（THP）/尿调蛋白是最丰富的尿蛋白，由亨利氏袢升支粗段产生。除了免疫功能外，它对离子转运和体积调节也有调节作用。关于远曲小管是否也是 THP 的来源一直存在争议。新的研究结果表明，在其早期部分，THP 的合成会影响上皮细胞的适应性可塑性，稳定钙稳态，并激活噻嗪类敏感的 Na+，Cl-共转运体。
