肠产毒性大肠杆菌感染促进仔猪细胞凋亡。
Enterotoxigenic Escherichia coli infection promotes apoptosis in piglets.
机构信息
Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, 410125, Hunan, China; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, China.
Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product, Safety of Ministry of Education of China, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
出版信息
Microb Pathog. 2018 Dec;125:290-294. doi: 10.1016/j.micpath.2018.09.032. Epub 2018 Sep 19.
Enterotoxigenic Escherichia coli (ETEC), as a universal pathogen, often causes diarrhea in animals and humans. However, whether ETEC infection induces apoptosis in host remains controversial. Herein, we use ETEC-infected piglet to investigate apoptosis in the jejunum. Apoptosis and the activation of capase-3 are observed in piglet jejunum after ETEC infection. Additionally, ETEC infection induces the activation of caspase-8 pathway, but inhibits the activation of caspase-9 pathway in piglet jejunum. These findings demonstrate that ETEC infection may inhibit the intrinsic pathway and activate the extrinsic pathway of apoptosis in piglets.
肠产毒性大肠杆菌（ETEC）作为一种普遍存在的病原体，常引起动物和人类腹泻。然而，ETEC 感染是否会诱导宿主细胞凋亡仍存在争议。本研究采用 ETEC 感染仔猪模型来研究空肠细胞凋亡情况。结果显示，ETEC 感染仔猪后空肠发生凋亡，同时 caspase-3 被激活。此外，ETEC 感染还诱导仔猪空肠中 caspase-8 途径的激活，同时抑制 caspase-9 途径的激活。这些结果表明，ETEC 感染可能抑制仔猪细胞的内在凋亡途径，并激活外在凋亡途径。
Zotero 插件