肠产毒性大肠杆菌感染促进仔猪细胞凋亡。

Enterotoxigenic Escherichia coli infection promotes apoptosis in piglets.

机构信息

Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, 410125, Hunan, China; Guangdong Provincial Key Laboratory of Animal Nutrition Control, Institute of Subtropical Animal Nutrition and Feed, College of Animal Science, South China Agricultural University, Guangzhou, China.

Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Joint International Research Laboratory of Agriculture and Agri-Product, Safety of Ministry of Education of China, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.

出版信息

Microb Pathog. 2018 Dec;125:290-294. doi: 10.1016/j.micpath.2018.09.032. Epub 2018 Sep 19.

DOI:10.1016/j.micpath.2018.09.032

PMID:30243552

Abstract

Enterotoxigenic Escherichia coli (ETEC), as a universal pathogen, often causes diarrhea in animals and humans. However, whether ETEC infection induces apoptosis in host remains controversial. Herein, we use ETEC-infected piglet to investigate apoptosis in the jejunum. Apoptosis and the activation of capase-3 are observed in piglet jejunum after ETEC infection. Additionally, ETEC infection induces the activation of caspase-8 pathway, but inhibits the activation of caspase-9 pathway in piglet jejunum. These findings demonstrate that ETEC infection may inhibit the intrinsic pathway and activate the extrinsic pathway of apoptosis in piglets.

摘要

肠产毒性大肠杆菌（ETEC）作为一种普遍存在的病原体，常引起动物和人类腹泻。然而，ETEC 感染是否会诱导宿主细胞凋亡仍存在争议。本研究采用 ETEC 感染仔猪模型来研究空肠细胞凋亡情况。结果显示，ETEC 感染仔猪后空肠发生凋亡，同时 caspase-3 被激活。此外，ETEC 感染还诱导仔猪空肠中 caspase-8 途径的激活，同时抑制 caspase-9 途径的激活。这些结果表明，ETEC 感染可能抑制仔猪细胞的内在凋亡途径，并激活外在凋亡途径。