Goudriaan Wouter Alexander, Harsevoort Gerrit Jan, van Leeuwen Marije, Franken Antonius Adrianus, Janus Guus Johannes Maria
Department of Orthopaedic Surgery, Isala, Zwolle, The Netherlands.
Department of Internal Medicine, Isala, Zwolle, The Netherlands.
Eur J Trauma Emerg Surg. 2020 Feb;46(1):165-171. doi: 10.1007/s00068-018-1005-9. Epub 2018 Sep 22.
Osteogenesis imperfecta (OI) is characterized by increased bone fragility and susceptibility for fractures. A few studies described and compared treatment modalities for femur fractures in children with OI. However, no cohort studies on adults with OI have been published. This study on adult OI patients aims to give insight into the incidence of femur fractures and non-unions and its best treatment options to avert non-union.
In this retrospective, descriptive study of the OI expert clinic in The Netherlands, all medical charts of patients 16 years or older were analyzed for femur fracture incidence, non-union rate and treatment modality.
Of 216 OI patients, 34 patients suffered a femur fracture with 12 patients having more than 1 femur fracture. For all types of femur fractures, the incidence was 651 fractures per 100,000 person-years annually. In 49 total fractures, 10 fractures resulted in a non-union, mostly shaft fractures of type 4 OI patients. Surgically treated shaft fractures had the best outcomes for non-union.
OI adults were prone to developing femur fractures and non-unions. Especially type 4 OI adults, with conservatively treated shaft fractures, were at high risk for non-unions.
成骨不全症（OI）的特征是骨脆性增加和易发生骨折。一些研究描述并比较了OI患儿股骨骨折的治疗方式。然而，尚未发表关于成年OI患者的队列研究。这项针对成年OI患者的研究旨在深入了解股骨骨折和骨不连的发生率以及避免骨不连的最佳治疗选择。
在这项对荷兰OI专家门诊进行的回顾性描述性研究中，分析了所有16岁及以上患者的病历，以了解股骨骨折发生率、骨不连率和治疗方式。
在216例OI患者中，34例发生了股骨骨折，其中12例有不止一次股骨骨折。所有类型的股骨骨折年发生率为每10万人年651例骨折。在49例骨折中，10例发生骨不连，主要是4型OI患者的骨干骨折。手术治疗的骨干骨折骨不连的治疗效果最佳。
成年OI患者容易发生股骨骨折和骨不连。尤其是4型成年OI患者，其骨干骨折采用保守治疗时，发生骨不连的风险很高。
