Sugita M, Masuda Y, Tsuchiya K
Am J Ind Med. 1986;10(4):411-7. doi: 10.1002/ajim.4700100408.
Health examinations of 108 workers exposed to vinyl chloride monomer (VCM) at a Japanese chemical plant were carried out in 1979. The polymerization of vinyl chloride was started at the plant in 1949. In this study, the highest concentration of VCM in autoclaves was determined to be 250 ppm in 1961. However, the workers at the plant had been exposed to higher concentrations of VCM several times before 1960. More recent VCM exposure was considered negligible. Examinations assessed data on age, height, weight, obesity index, sake consumption, VCM exposure concentration, latent period, cumulative exposure, ICG (indocyano green test), serum bilirubin, GOT (glutamic oxaloacetic transaminase), GPT (glutamic pyruvic transaminase), A1-P (alkaline phosphatase), GGT(gamma-glutamyl transpeptidase), ZTT (zinc turbidity test), LDH (lactate dehydrogenase), cholesterol, TTT (thymol turbidity test), A/G (albumin globulin ratio), and thrombocytes. Variation in VCM exposure did not affect tests of pigment excretion from the liver, such as ICG; thrombocytes; and enzyme activity (such as GPT); nor bilirubin or flocculation reaction in serum.
1979年，对日本一家化工厂108名接触氯乙烯单体（VCM）的工人进行了健康检查。该化工厂于1949年开始氯乙烯聚合生产。在本研究中，1961年高压釜中VCM的最高浓度测定为250 ppm。然而，该工厂的工人在1960年之前曾多次接触更高浓度的VCM。最近的VCM接触被认为可忽略不计。检查评估了年龄、身高、体重、肥胖指数、清酒摄入量、VCM接触浓度、潜伏期、累积接触量、吲哚氰绿试验（ICG）、血清胆红素、谷草转氨酶（GOT）、谷丙转氨酶（GPT）、碱性磷酸酶（A1-P）、γ-谷氨酰转肽酶（GGT）、锌浊度试验（ZTT）、乳酸脱氢酶（LDH）、胆固醇、麝香草酚浊度试验（TTT）、白蛋白球蛋白比值（A/G）和血小板的数据。VCM接触量的变化对肝脏色素排泄试验（如ICG）、血小板以及酶活性（如GPT）、血清胆红素或絮凝反应均无影响。
