Vincent-Viry M, La Du B N, Lepage L, Mikstacki T
Ann Biol Clin (Paris). 1986;44(3):233-8.
Earlier studies show that there is a polymorphism of the paraoxonase and that the heterozygous phenotype can be distinguished from both homozygous phenotypes, by studying the ratio of paraoxonase to arylesterase activities. The separation of the three phenotypes of the paraoxonase was possible on our population using the same techniques as Eckerson et al. and by a statistic method from Schroeder, 32 families have been studied. The gene frequencies for the A and B alleles are: 0.6875 and 0.3125 respectively in a french population. They are very close to those of an American Caucasian population: A: 0.685 and B: 0.315 of Eckerson et al.
早期研究表明，对氧磷酶存在多态性，通过研究对氧磷酶与芳基酯酶活性的比率，杂合子表型可与两种纯合子表型区分开来。在我们的人群中，使用与埃克森等人相同的技术，并通过施罗德的统计方法，能够分离出对氧磷酶的三种表型，已对32个家庭进行了研究。在法国人群中，A和B等位基因的基因频率分别为0.6875和0.3125。它们与美国白种人群体的基因频率非常接近：埃克森等人研究的美国白种人群体中，A为0.685，B为0.315。
