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继发性甲状旁腺功能亢进患者颈椎棕色瘤:一例报告

Brown tumor of the cervical spine in a patient with secondary hyperparathyroidism: A case report.

作者信息

Sánchez-Calderón Mauricio Daniel, Ochoa-Cacique Diego, Medina Carrillo Oscar, García González Ulises, Vicuña González Rosa María, Bravo Reyna Carlos Cesar, Guerra-Mora José Raúl

机构信息

Department of Neurology and Neurosurgery, South Central High Specialty Hospital, Pemex, Mexico.

Neurology and Neurosurgery Department, South Central High Specialty Hospital, Pemex, Mexico.

出版信息

Int J Surg Case Rep. 2018;51:328-330. doi: 10.1016/j.ijscr.2018.09.023. Epub 2018 Sep 18.

DOI:10.1016/j.ijscr.2018.09.023
PMID:30245355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6153394/
Abstract

INTRODUCTION

Brown tumors are non-neoplastic, expansive bone lesions that occur only in the setting of hyperparathyroidism. The most usual localization of brown tumors is in mandible, ribs and large bones. In cervical spine, to date, there are only 11 cases reported. The aim of this work is to report the case of a patient with Wegener´s granulomatosis with secondary end stage renal failure who developed a brown tumor in C4 vertebra.

PRESENTATION OF CASE

A 25-year-old woman with an history of 2 months of worsening cervicalgia without history of trauma. She complained about progressive neck pain with irradiation to both shoulders and right arm paresthesias, spontaneous fracture or brown spinal cord tumor were suspected. She presented cervical spine instability, was managed with corpectomy of C4 and biopsy.

DISCUSSION

The initial suspicion of this disease must be since the first clinician contact of the patient and with the past medical history of end stage renal failure plus recent neurologic manifestations. The aim of neurosurgical management of these patients is to promote spinal stability and release spinal cord and nerve roots to eliminate risk of neurological deficits.

CONCLUSION

The importance of the prompt diagnosis of the brown tumor is to establish a multidisciplinary management to prevent progression, neurologic complications and sequelae despite its benign behavior.

摘要

引言

棕色瘤是非肿瘤性、膨胀性骨病变,仅发生于甲状旁腺功能亢进的情况下。棕色瘤最常见的部位是下颌骨、肋骨和大骨。迄今为止,颈椎部位仅有11例报道。本文旨在报告1例韦格纳肉芽肿继发终末期肾衰竭患者,其在C4椎体发生棕色瘤的病例。

病例介绍

一名25岁女性,有2个月颈部疼痛加重病史,无外伤史。她主诉颈部疼痛进行性加重,放射至双肩,右臂有感觉异常,怀疑有自发性骨折或棕色脊髓瘤。她出现颈椎不稳,接受了C4椎体次全切除及活检。

讨论

从患者首次就诊及既往终末期肾衰竭病史加上近期神经系统表现开始,就必须初步怀疑该病。对这些患者进行神经外科治疗的目的是促进脊柱稳定,解除脊髓和神经根压迫,消除神经功能缺损风险。

结论

尽管棕色瘤表现为良性,但及时诊断的重要性在于建立多学科治疗方案,以防止病情进展、神经并发症及后遗症。

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本文引用的文献

1
Complex spinal fixation of a cervical vertebra Brown tumour: report of an unusual case.
Br J Neurosurg. 2019 Dec;33(6):684-686. doi: 10.1080/02688697.2017.1406059. Epub 2017 Nov 21.
2
The SCARE Statement: Consensus-based surgical case report guidelines.SCARE 声明:基于共识的外科手术病例报告指南。
Int J Surg. 2016 Oct;34:180-186. doi: 10.1016/j.ijsu.2016.08.014. Epub 2016 Sep 7.
3
A thoracic vertebral brown tumor presenting with paraparesis in a patient with end-stage renal disease.一名终末期肾病患者出现截瘫的胸椎棕色瘤。
一例罕见的枢椎“棕色瘤”伴甲状旁腺腺瘤及三发性甲状旁腺功能亢进。
J Craniovertebr Junction Spine. 2023 Jan-Mar;14(1):97-102. doi: 10.4103/jcvjs.jcvjs_144_22. Epub 2023 Mar 13.
4
Missed C5 vertebral brown tumor causing spinal cord compression and myelopathy: A case report and literature review.漏诊的C5椎体棕色瘤导致脊髓压迫和脊髓病:一例报告及文献综述
Clin Case Rep. 2022 Jan 28;10(1):e05331. doi: 10.1002/ccr3.5331. eCollection 2022 Jan.
Br J Neurosurg. 2017 Dec;31(6):635-637. doi: 10.1080/02688697.2016.1199789. Epub 2016 Jun 24.
4
Cervical burst fracture caused by brown tumor.
Neurol India. 2015 Jan-Feb;63(1):110-2. doi: 10.4103/0028-3886.152680.
5
Brown tumor of the cervical spines: a case report with literature review.颈椎棕色瘤:一例病例报告并文献复习
Asian Spine J. 2015 Feb;9(1):110-20. doi: 10.4184/asj.2015.9.1.110. Epub 2015 Feb 13.
6
Unusual clinical presentation of brown tumor in hemodialysis patients: two case reports.血液透析患者棕色瘤的不典型临床表现:两例报告。
Int Urol Nephrol. 2011 Jun;43(2):575-80. doi: 10.1007/s11255-010-9738-3. Epub 2010 Apr 28.
7
Chronic renal failure causing brown tumors and myelopathy. Case report and review of pathophysiology and treatment.慢性肾衰竭导致棕色瘤和脊髓病。病例报告及病理生理学与治疗的综述
J Neurosurg. 1999 Apr;90(2 Suppl):242-6. doi: 10.3171/spi.1999.90.2.0242.
8
Brown tumor of the cervical spine.
Spine (Phila Pa 1976). 1993 Jun 1;18(7):936-7. doi: 10.1097/00007632-199306000-00023.