阿尔茨海默病患者脑脊液中CX3CL1水平降低。
Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease.
作者信息
Perea Juan R, Lleó Alberto, Alcolea Daniel, Fortea Juan, Ávila Jesús, Bolós Marta
机构信息
Department of Molecular Neuropathology, Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Network Center for Biomedical Research on Neurodegenerative Diseases, Madrid, Spain.
出版信息
Front Neurosci. 2018 Sep 7;12:609. doi: 10.3389/fnins.2018.00609. eCollection 2018.
Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of neurofibrillary tangles, constituted by tau protein, and plaques formed by amyloid-beta protein. The disease courses with high neural damage, which leads to memory loss and death. Here we analyzed the presence of CX3CL1, a chemokine expressed by neurons, in cerebrospinal fluid (CSF) samples from control subjects and patients with mild cognitive impairment and AD dementia. CX3CL1 was decreased in the CSF of AD dementia patients compared to control subjects. However, there was not difference in plasma samples from the same subjects.
阿尔茨海默病（AD）是一种神经退行性疾病，其特征是存在由tau蛋白构成的神经原纤维缠结以及由β-淀粉样蛋白形成的斑块。该疾病伴随着严重的神经损伤，导致记忆丧失和死亡。在此，我们分析了来自对照受试者以及轻度认知障碍和AD痴呆患者的脑脊液（CSF）样本中神经元表达的趋化因子CX3CL1的存在情况。与对照受试者相比，AD痴呆患者脑脊液中的CX3CL1减少。然而，同一受试者的血浆样本中没有差异。
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