狒狒（Papio spp.）胎盘出现首例肝细胞癌。
A first case of hepatocellular carcinoma in the baboon (Papio spp.) placenta.
作者信息
Schlabritz-Loutsevitch Natalia, Carrillo Maira, Li Cun, Nathanielsz Peter, Maguire Christopher, Maher James, Dick Edward, Hubbard Gene, Stanek Jerzy
机构信息
Texas Tech University Health Sciences Center at the Permian Basin, Odessa, Texas.
University of Wyoming, Laramie, Wyoming.
出版信息
J Med Primatol. 2019 Feb;48(1):68-73. doi: 10.1111/jmp.12382. Epub 2018 Sep 24.
We present a case of hepatocellular carcinoma (HCC) in the placenta of healthy baboon (Papio spp.). Grossly, the fetal, maternal, and placental tissues were unremarkable. Histologically, the placenta contained an unencapsulated, poorly demarcated, infiltrative, solidly cellular neoplasm composed of cells that resembled hepatocytes. The neoplastic cells were diffusely positive for vimentin and focally positive for Ae1/Ae3, Arginase -1, glutamine synthetase, and CD10, and negative for ER, vascular markers (CD31 and D240), S100, glypican, C-reactive protein, FABP, desmin, and beta-catenin; INI1 positivity was similar to non-neoplastic tissues. The case likely represents a unique subtype of HCC.
我们报告一例健康狒狒（Papio spp.）胎盘发生肝细胞癌（HCC）的病例。大体上，胎儿、母体和胎盘组织均无异常。组织学检查显示，胎盘内有一个未被包膜包裹、边界不清、浸润性生长、细胞密集的实性肿瘤，由类似肝细胞的细胞组成。肿瘤细胞波形蛋白弥漫性阳性，细胞角蛋白AE1/AE3、精氨酸酶-1、谷氨酰胺合成酶和CD10局灶性阳性，雌激素受体（ER）、血管标志物（CD31和D240）、S100、磷脂酰肌醇蛋白聚糖、C反应蛋白、脂肪酸结合蛋白（FABP）、结蛋白和β-连环蛋白阴性；INI1阳性情况与非肿瘤组织相似。该病例可能代表HCC的一种独特亚型。
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