钒酸盐对大鼠空肠水和电解质转运的影响。

Effects of vanadate on water and electrolyte transport in rat jejunum.

作者信息

Hajjar J J, Zakko S, Tomicic T K

出版信息

Biochim Biophys Acta. 1986 Dec 16;863(2):325-8. doi: 10.1016/0005-2736(86)90275-0.

Abstract

The effect of vanadate (orthovanadate, VO4-) on water and ion transport was studied in rat jejunum. Water transport was tested by single-pass perfusion in vivo and ion fluxes by the Ussing-chamber technique in vitro. The results suggest that vanadate has two actions on ion and water transport: At low concentrations (10(-4) M) it causes Cl-, Na+ and water secretion by stimulation of adenylate cyclase; At higher concentrations (10(-3) and 10(-2) M) it decreases net absorption of Na+ and Cl- by inhibition of (Na+ + K+)-ATPase.

摘要

研究了钒酸盐（原钒酸盐，VO4-）对大鼠空肠水和离子转运的影响。通过体内单通道灌注测试水转运，通过体外尤斯灌流小室技术测试离子通量。结果表明，钒酸盐对离子和水转运有两种作用：在低浓度（10^(-4) M）时，它通过刺激腺苷酸环化酶引起Cl-、Na+和水分泌；在较高浓度（10^(-3)和10^(-2) M）时，它通过抑制（Na+ + K+）-ATP酶减少Na+和Cl-的净吸收。