Hatch M, Freel R W, Goldner A M, Earnest D L
Biochim Biophys Acta. 1983 Aug 10;732(3):699-704. doi: 10.1016/0005-2736(83)90249-3.
Ionized forms of vanadium are known to exert diverse biological activities. Of particular interest in the inhibitory action of the vanadium ion on (Na+ + K+)-ATPase. This report describes another action of the vanadium ion on the rabbit colonic epithelium. Micromolar quantities of vanadate, applied to the serosal side of the isolated rabbit colonic epithelium, result in a stimulation of electrogenic chloride secretion by this epithelium. Sodium transport is unaffected by the vanadium ion in the concentrations used in this study. It is proposed that the vanadyl ion activates adenylate cyclase and thereby initiates subsequent secretory events.
已知钒的离子形式具有多种生物活性。特别值得关注的是钒离子对（Na+ + K+）-ATP酶的抑制作用。本报告描述了钒离子对兔结肠上皮细胞的另一种作用。将微摩尔量的钒酸盐应用于分离的兔结肠上皮细胞的浆膜侧，会刺激该上皮细胞产生电致性氯化物分泌。在本研究中使用的浓度下，钠转运不受钒离子影响。有人提出钒酰离子激活腺苷酸环化酶，从而引发后续的分泌事件。
