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使用定制三维打印支架进行先天性无鼻畸形鼻再造:三年随访

Nasal Reconstruction Using a Customized Three-Dimensional-Printed Stent for Congenital Arhinia: Three-Year Follow-up.

作者信息

Jung Jin Woo, Ha Dong-Heon, Kim Boo Young, Seo Bommie F, Han Hyun Ho, Kim Do Hyun, Rhie Jong-Won, Kim Sung Won, Cho Dong-Woo

机构信息

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, South Korea.

Department of Otolaryngology-Head and Neck Surgery, Seoul, South Korea.

出版信息

Laryngoscope. 2019 Mar;129(3):582-585. doi: 10.1002/lary.27335. Epub 2018 Sep 24.

Abstract

A male Mongolian child with a complete congenital absence of both nose and nasal passage had a poor survival prognosis due to respiratory distress. To enable his survival, a new nose capable of conferring respiratory function was constructed. Following reconstructive surgery, an absence of mucoepithelium in the nasal passage can lead to rhinostenosis. To avoid this complication, a custom-made nasal silicone stent was created using three-dimensional (3D) printing technology in conjunction with the patient's computed tomography data. The stent was implanted for 2 months to maintain the shape and size of the nasal passage. At 2 months after stent implantation, the mucoepithelium tissue in the passage had successfully regenerated with no immune reaction. Three years after stent removal, respiratory function, nasal passage structure, and external nose shape were maintained without additional medical care. These results indicate the successful nasal reconstruction in an arhinia patient using a customized, 3D-printed nasal stent. Laryngoscope, 129:582-585, 2019.

摘要

一名蒙古男童先天性完全缺失鼻子及鼻腔通道,因呼吸窘迫生存预后较差。为使其存活,构建了一个具备呼吸功能的新鼻子。重建手术后,鼻腔通道缺乏黏膜上皮可导致鼻狭窄。为避免这一并发症,结合患者的计算机断层扫描数据,利用三维(3D)打印技术制作了一个定制的鼻硅胶支架。该支架植入2个月以维持鼻腔通道的形状和大小。支架植入2个月后,通道内的黏膜上皮组织成功再生,且无免疫反应。支架取出3年后,呼吸功能、鼻腔通道结构及外鼻形状得以维持,无需额外医疗护理。这些结果表明,使用定制的3D打印鼻支架在无鼻患者中成功进行了鼻重建。《喉镜》,2019年,第129卷,第582 - 585页

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