孕早期和孕中期母体癫痫的生化标志物：一项病例对照研究。
First and Second Trimester Biochemical Markers in Maternal Epilepsy: A Case-Control Study.
作者信息
Oksuzoglu Aysegul, Engin Ustun Yaprak, Aktulay Ayla, Yoruk Ozlem, Seckin Berna, Danisman Nuri
机构信息
a Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Research and Education Hospital , Ankara , Turkey.
出版信息
Fetal Pediatr Pathol. 2018 Oct;37(5):319-325. doi: 10.1080/15513815.2018.1502381. Epub 2018 Sep 24.
BACKGROUND
Our aim is to investigate whether the maternal serum levels of first and second trimester serum analytes are altered in women with epilepsy in pregnancy.
METHODS
Maternal serum biochemical markers (estriol, alpha-fetoprotein [AFP], human chorionic gonadotrophin [hCG], free β hCG, pregnancy-associated plasma protein-A) were compared in a series of 122 pregnant women with epilepsy and in a cohort of 122 normal pregnant women. The serum samples were obtained between 11-13 6/7 weeks and 16-18 weeks gestation.
RESULTS
Second trimester serum estriol levels, expressed as multiples of the median (MoM), in the epileptic group (1.55 ± 0.77 MoM) were significantly higher than those in the control patients (1.13 ± 0.40 MoM) (p < 0.001). Of the women with epilepsy, 66.3% (n = 81) were exposed to antiepileptic drugs.
CONCLUSION
Our study revealed that otherwise uncomplicated pregnant epileptic women had higher second trimester (18-20 weeks of gestation) estriol levels compared to non-epileptic pregnant women.
背景
我们的目的是研究妊娠合并癫痫的女性孕早期和孕中期血清分析物水平是否发生改变。
方法
对122例妊娠合并癫痫的孕妇和122例正常孕妇队列的母体血清生化标志物（雌三醇、甲胎蛋白[AFP]、人绒毛膜促性腺激素[hCG]、游离β-hCG、妊娠相关血浆蛋白-A）进行比较。血清样本在妊娠11-13⁶/₇周和16-18周期间采集。
结果
癫痫组孕中期血清雌三醇水平以中位数倍数（MoM）表示为（1.55±0.77 MoM），显著高于对照组患者（1.13±0.40 MoM）（p<0.001）。癫痫女性中有66.3%（n = 81）暴露于抗癫痫药物。
结论
我们的研究表明，与非癫痫孕妇相比，妊娠合并癫痫且无其他并发症的女性孕中期（妊娠18-20周）雌三醇水平更高。
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