Department of Internal Medicine and Medical Specialities, Section of Geriatrics, University of Genoa, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
DISSAL, Department of Health Science, University of Genoa, Italy.
J Alzheimers Dis. 2018;66(1):281-288. doi: 10.3233/JAD-180153.
Hip fracture is a major health problem and a patient's biological age, comorbidity, and cognitive vulnerability have an impact on its related outcomes. Length of stay (LOS) for these highly vulnerable patients is rather long and the possible causes have not been clearly identified yet.
We aimed to assess the main clinical factors associated with protracted LOS, focusing on delirium with or without dementia in older age hip fractured patients.
218 subjects (mean age 86.70±6.18 years), admitted to the Orthogeriatric Unit of the Ospedale Policlinico San Martino (Italy), were recruited. All patients received physical and comprehensive geriatric assessment. Days to surgery, days from surgery to rehabilitation, and LOS were recorded. In-hospital and three months' mortality were reported.
Prevalent delirium at hospital admission was of 3.1%. 35% of patients developed incident delirium. 56.4% were affected by dementia of Alzheimer-type. In addition, 52% of patients developed delirium superimposed to dementia. Mean LOS was 13.5±4.99 days. Namely, delirium, time to surgery, and complication rate disproportionally affected LOS. The analysis with 3 months mortality, based on cognitive vulnerability profiles, showed how delirium mainly affect short-term mortality in patients with dementia.
Our exploratory study originally pointed out the high incidence of delirium superimposed to dementia in orthogeriatric wards and how delirium turns to be a moderator of LOS. The results meet the need for additional research by virtue of a deeper understanding of the impact of delirium and dementia on orthogeriatric clinical management and outcomes.
髋部骨折是一个主要的健康问题,患者的生物年龄、合并症和认知脆弱性对其相关结局有影响。这些高度脆弱的患者的住院时间(LOS)相当长,但其可能的原因尚未明确。
我们旨在评估与延长 LOS 相关的主要临床因素,重点关注老年髋部骨折患者伴或不伴痴呆的谵妄。
我们招募了 218 名(平均年龄 86.70±6.18 岁)入住意大利圣马蒂诺综合医院骨科老年病房的患者。所有患者均接受了身体和全面的老年评估。记录了手术前的天数、手术后到康复的天数和 LOS。报告了住院期间和 3 个月的死亡率。
入院时存在的谵妄发生率为 3.1%。35%的患者发生了新发谵妄。56.4%的患者患有阿尔茨海默病型痴呆。此外,52%的患者发生了痴呆合并谵妄。平均 LOS 为 13.5±4.99 天。即谵妄、手术时间和并发症发生率不成比例地影响 LOS。基于认知脆弱性特征的 3 个月死亡率分析表明,谵妄如何主要影响痴呆患者的短期死亡率。
我们的探索性研究最初指出了在骨科老年病房中合并痴呆的谵妄发生率很高,以及谵妄如何成为 LOS 的调节剂。这些结果满足了通过深入了解谵妄和痴呆对骨科老年临床管理和结局的影响来进行进一步研究的需求。