来自少花樟味藜的异黄酮抑制有机阴离子转运体OAT1和OAT3。

Isoflavones from Camphorosma lessingii Inhibit the Organic Anion Transporters OAT1 and OAT3.

作者信息

Wang Xinhui, Wang Dujuan, Wang Xue, Khutsishvili Manana, Tamanyan Kamilla, Fayvush George, Atha Daniel, Zhang Youcai, Borris Robert P

机构信息

School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, China.

National Herbarium of Georgia, Ilia State University, Tbilisi, Georgia.

出版信息

Planta Med. 2019 Feb;85(3):225-230. doi: 10.1055/a-0740-3255. Epub 2018 Sep 24.

DOI:10.1055/a-0740-3255

PMID:30248705

Abstract

Phytochemical investigation of has resulted in the isolation of four previously unreported isoflavones (1: -4: ) and eight known compounds (5: -12: ). Nine of these compounds (1: -6, 8: -10: ) are reported for the first time from members of the family Amaranthaceae. The structures of all isolated compounds were determined by spectroscopic methods, primarily one-dimensional and two-dimensional nuclear magnetic resonance and mass spectrometry. The absolute configuration of 6: was confirmed by circular dichroism. Inhibition of the organic anion transporters, OAT1 and OAT3, by the isolated compounds was evaluated. Among them, 7, 2'-dihydroxy- 6,8-dimethoxyisoflavone (1: ), 2'-hydroxy-6,7,8-trimethoxyisoflavone (2: ), 6,2'-dihydroxy-7,8-dimethoxyisoflavone (3: ), and 7-methoxyflavone (5: ) showed a significant inhibitory effect on 6-carboxyfluorescein uptake mediated by OAT1 and OAT3.

摘要

对……进行植物化学研究已分离出四种先前未报道的异黄酮（1： - 4：）和八种已知化合物（5： - 12：）。其中九种化合物（1： - 6，8： - 10：）首次从苋科植物中报道。所有分离化合物的结构通过光谱方法确定，主要是一维和二维核磁共振以及质谱。6：的绝对构型通过圆二色性得到确证。评估了分离出的化合物对有机阴离子转运体OAT1和OAT3的抑制作用。其中，7, 2'-二羟基 - 6,8 - 二甲氧基异黄酮（1：）、2'-羟基 - 6,7,8 - 三甲氧基异黄酮（2：）、6,2'-二羟基 - 7,8 - 二甲氧基异黄酮（3：）和7 - 甲氧基黄酮（5：）对OAT1和OAT3介导的6 - 羧基荧光素摄取显示出显著的抑制作用。