Milsom S R, Donald R A, Espiner E A, Nicholls M G, Livesey J H
Clin Endocrinol (Oxf). 1986 Sep;25(3):241-6. doi: 10.1111/j.1365-2265.1986.tb01688.x.
To evaluate the effect of changes in plasma catecholamines on the pituitary-adrenal response to ovine corticotrophin releasing factor (CRF) in normal man, the response to CRF alone (10 subjects) was compared responses after infusions of adrenaline (6 subjects), noradrenaline (6 subjects) and after oral administration of the alpha 2 agonist clonidine (10 subjects). Compared to control levels, plasma adrenaline and noradrenaline concentrations were increased three- and four-fold respectively by exogenous infusions, whereas plasma noradrenaline was significantly lowered by clonidine. Despite these changes in plasma catecholamine levels, the responses of plasma ACTH, cortisol and aldosterone to CRF did not differ significantly from control (CRF alone) in any of the three studies. Neither clonidine pretreatment nor catecholamine infusions altered basal levels of plasma ACTH, cortisol or aldosterone and no effect of CRF or catecholamine manipulations on plasma arginine vasopressin concentration was observed. These results show that modulation of peripheral plasma catecholamine levels within physiological limits does not affect CRF-stimulated release of ACTH or the adrenal response in normal man.
为评估正常人体内血浆儿茶酚胺变化对垂体 - 肾上腺对羊促肾上腺皮质激素释放因子（CRF）反应的影响，将单独给予CRF的反应（10名受试者）与输注肾上腺素后（6名受试者）、去甲肾上腺素后（6名受试者）以及口服α2激动剂可乐定后（10名受试者）的反应进行了比较。与对照水平相比，外源性输注使血浆肾上腺素和去甲肾上腺素浓度分别增加了三倍和四倍，而可乐定使血浆去甲肾上腺素显著降低。尽管血浆儿茶酚胺水平发生了这些变化，但在三项研究中的任何一项中，血浆促肾上腺皮质激素（ACTH）、皮质醇和醛固酮对CRF的反应与对照（仅CRF）相比均无显著差异。可乐定预处理和儿茶酚胺输注均未改变血浆ACTH、皮质醇或醛固酮的基础水平，且未观察到CRF或儿茶酚胺操作对血浆精氨酸加压素浓度有影响。这些结果表明，在生理范围内调节外周血浆儿茶酚胺水平不会影响正常人体内CRF刺激的ACTH释放或肾上腺反应。
