Alves Kristin, Penny Norgrove, Ekure John, Olupot Robert, Kobusingye Olive, Katz Jeffrey N, Sabatini Coleen S
Harvard Combined Orthopaedic Surgery Residency Program, Boston, MA, USA.
Department of Orthopaedic Surgery, Brigham and Women's Hospital, Boston, MA, USA.
BMC Musculoskelet Disord. 2018 Sep 24;19(1):343. doi: 10.1186/s12891-018-2254-9.
The purpose of this study was to estimate the prevalence of postinjection paralysis (PIP) and gluteal fibrosis (GF) among children treated in a rural Ugandan Hospital.
We conducted a retrospective cohort study by reviewing the musculoskeletal clinic and community outreach logs for children (age < 18 yrs) diagnosed with either PIP or GF from Kumi Hospital in Kumi, Uganda between 2013 and 2015. We estimated the prevalence as a ratio of the number of children seen with each disorder over the total population of children seen for any musculoskeletal complaint in musculoskeletal clinic and total population of children seen for any medical complaint in the outreach clinic.
Of 1513 children seen in the musculoskeletal clinic, 331 (21.9% (95% CI 19.8-24.1%)) had PIP and another 258 (17.1% (95% CI 15.2-19.0%)) had GF as their diagnosis. Of 3339 children seen during outreach for any medical complaint, 283 (8.5% (95% CI 7.6-9.5%)) had PIP and another 1114 (33.4% (95% CI 31.8-35.0%)) had GF. Of patients with GF, 53.9% were male with a median age of 10 years (50% between 7 and 12 years old). Of patients with PIP, 56.7% were male with a median age of 5 years (50% between 2 and 8 years old).
PIP and GF comprise over 30% of clinical visits for musculoskeletal conditions and 40% of outreach visits for any medical complaint in this area of Uganda. The high estimated prevalence in these populations suggest a critical need for research, treatment, and prevention.
本研究旨在评估乌干达一家乡村医院收治儿童中注射后麻痹（PIP）和臀肌纤维化（GF）的患病率。
我们进行了一项回顾性队列研究，查阅了2013年至2015年间乌干达库米市库米医院诊断为PIP或GF的儿童（年龄＜18岁）的肌肉骨骼门诊和社区外展记录。我们将患病率估计为肌肉骨骼门诊中因任何肌肉骨骼疾病就诊的儿童总数中出现每种疾病的儿童数量之比，以及外展门诊中因任何医疗疾病就诊的儿童总数中出现每种疾病的儿童数量之比。
在肌肉骨骼门诊就诊的1513名儿童中，331名（21.9%（95%可信区间19.8 - 24.1%））诊断为PIP，另有258名（17.1%（95%可信区间15.2 - 19.0%））诊断为GF。在因任何医疗疾病进行外展服务时就诊的3339名儿童中，283名（8.5%（95%可信区间7.6 - 9.5%））诊断为PIP，另有1114名（33.4%（95%可信区间31.8 - 35.0%））诊断为GF。在GF患者中，53.9%为男性，中位年龄为10岁（50%在7至12岁之间）。在PIP患者中，56.7%为男性，中位年龄为5岁（50%在2至8岁之间）。
在乌干达的这一地区，PIP和GF占肌肉骨骼疾病临床就诊病例的30%以上，占任何医疗疾病外展就诊病例的40%。这些人群中估计的高患病率表明迫切需要进行研究、治疗和预防。
