鞣花酸对果蝇感染模型中白色念珠菌的疗效。
Efficacy of Ellagic Acid against Candida albicans in a Drosophila melanogaster Infection Model.
机构信息
Department of Environmental Engineering and Oral Biopathology Graduate Program, São José dos Campos Institute of Science and Technology, Universidade Estadual Paulista (UNESP), São José dos Campos, Brazil.
Institute of Biomedical Sciences, Federal University of Rio de Janeiro (UFRJ), National Institute of Science and Technology in Molecular Entomology (INCT-EM), Rio de Janeiro, Brazil.
出版信息
Antimicrob Agents Chemother. 2018 Nov 26;62(12). doi: 10.1128/AAC.01716-18. Print 2018 Dec.
Abstract
The aim of this study was to evaluate the antifungal activity and the toxicity of ellagic acid (EA) using a model. bacteria were inoculated into Toll heterozygous flies. Survival curves were obtained for the evaluation of the antimicrobial effect and toxicity of EA. A protective effect of EA against fungal infection in was observed at nontoxic concentrations. This study showed that EA is a promising tool for the treatment of candidiasis.
摘要
本研究旨在评估鞣花酸（EA）的抗真菌活性和毒性。采用 Toll 杂合果蝇模型进行研究。将细菌接种到 Toll 杂合果蝇中，评估 EA 的抗菌效果和毒性。结果表明，在非毒性浓度下，EA 对果蝇的真菌感染具有保护作用。本研究表明，EA 是治疗念珠菌病的一种有前途的工具。
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