Wang Wenqin, Liu Wei, Zhang Ning, He Xiaodong
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100730, P.R. China.
Oncol Lett. 2018 Oct;16(4):4879-4888. doi: 10.3892/ol.2018.9285. Epub 2018 Aug 8.
The objective of the present study was to evaluate whether preoperative platelet-lymphocyte ratio (PLR) and neutrophil-lymphocyte ratio (NLR) could predict the prognosis for curative resected ampullary carcinoma. A total of 94 patients were retrospectively included over a 6-year period in which consecutive cases underwent pancreaticoduodenectomy for ampullary malignancy. Preoperative blood results were available in the 94 cases of resected ampullary carcinoma. Preoperative PLR and NLR cut-off values of 226.8 and 2.58 were determined to represent the optimal cut-off values in the cases for survival analysis. PLR remained a significant independent predictor of survival in multivariate analysis (Cox, P<0.001) in addition to tumor differentiation (P<0.001), nodal status (P<0.001) and stage (P<0.001). While NLR failed to serve as a prognostic factor in univariate (P=0.0637) and multivariate (P=0.164) survival analysis. Furthermore, the nodal involvement rate was higher in high PLR group (74.2 vs. 19.05%, P<0.001). Preoperative PLR and NLR merit further evaluation as a prognostic index in curative resected ampullary carcinoma. Additionally, it is a candidate predictor for the lymph node metastasis.
本研究的目的是评估术前血小板淋巴细胞比率（PLR）和中性粒细胞淋巴细胞比率（NLR）是否能够预测根治性切除的壶腹癌的预后。在6年期间，共有94例患者被纳入回顾性研究，这些连续病例均因壶腹恶性肿瘤接受了胰十二指肠切除术。94例接受壶腹癌切除术的患者均有术前血液检查结果。术前PLR和NLR的临界值分别确定为226.8和2.58，作为生存分析病例中的最佳临界值。在多因素分析中（Cox模型，P<0.001），除肿瘤分化（P<0.001）、淋巴结状态（P<0.001）和分期（P<0.001）外，PLR仍然是生存的显著独立预测因素。而NLR在单因素（P=0.0637）和多因素（P=0.164）生存分析中未能作为预后因素。此外，高PLR组的淋巴结受累率更高（74.2%对19.05%，P<0.001）。术前PLR和NLR作为根治性切除壶腹癌的预后指标值得进一步评估。此外，它是淋巴结转移的一个候选预测指标。
