Schepens Eye Research Institute, Massachusetts Eye and Ear, and Department of Ophthalmology, Harvard Medical School, Boston Massachusetts, USA.
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Stem Cells Transl Med. 2018 Dec;7(12):887-892. doi: 10.1002/sctm.18-0037. Epub 2018 Sep 24.
The meibomian gland (MG) is a sebaceous gland that secretes through a holocrine process. Because such secretion requires the destruction of MG acinar epithelial cells, they need constant renewal and differentiation. The processes that promote these regenerative events in the human MG are unknown, nor is it known how to distinguish MG progenitor and differentiated cells. We discovered that Lrig1 and DNase2 serve as biomarkers for human MG progenitor and differentiated cells, respectively. Lrig1 is expressed in MG basal epithelial cells in the acinar periphery, a location where progenitor cells originate in sebaceous glands. DNase2 is expressed in the differentiated epithelial cells of the MG central acinus. Furthermore, proliferation stimulates, and differentiation suppresses, Lrig1 expression in human MG epithelial cells. The opposite is true for DNase2 expression. Our biomarker identification may have significant value in clinical efforts to restore MG function and to regenerate MGs after disease-induced dropout. Stem Cells Translational Medicine 2018;7:887-892.
睑板腺（MG）是一种皮脂腺，通过全浆分泌。因为这种分泌需要破坏 MG 腺泡上皮细胞，所以它们需要不断更新和分化。促进人类 MG 中这些再生事件的过程尚不清楚，也不知道如何区分 MG 祖细胞和分化细胞。我们发现 Lrig1 和 DNase2 分别作为人类 MG 祖细胞和分化细胞的生物标志物。Lrig1 在 MG 腺泡周围的基底上皮细胞中表达，而腺泡起源于皮脂腺的祖细胞。DNase2 在 MG 中央腺泡的分化上皮细胞中表达。此外，增殖刺激 Lrig1 在人 MG 上皮细胞中的表达，而分化则抑制其表达。DNase2 的表达情况正好相反。我们的生物标志物鉴定可能对临床努力具有重要价值，以恢复 MG 的功能，并在疾病引起的脱落后再生 MG。《Stem Cells Translational Medicine》2018 年；7:887-892.
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