人绒毛膜促性腺激素（hCG）表达的重新激活。其在宫颈鳞状细胞癌诊断中的作用。
The re-awakening of hCG expression. Its role in the diagnosis of cervical squamous cell carcinoma.
作者信息
Bozdag Zehra, Taslar Aynur M, Tepe Neslihan B, Dizibuyuk Omer F, Ozcan Huseyin C, Karakök Metin
机构信息
Department of pathology, Faculty of Medicine, Gaziantep University. E-mail.
出版信息
Saudi Med J. 2018 Sep;39(9):873-877. doi: 10.15537/smj.2018.9.22710.
OBJECTIVES
To compare immunohistochemical detection of Human chorionic gonadotropin (hCG) expression in paraffin embedded tissue of squamous cell carcinomas (SCC) and high grade squamous intraepithelial lesions (HSIL).
METHODS
The samples in this retrospective study were obtained from the archives of the Pathology Department at Gaziantep University, Gaziantep, Turkey, over the period from January 2012 to September 2016. The study group consisted of 55 cases of SCC and 45 cases of HSIL. Tissue expression of hCG was detected by specific binding of anti-hCG antibody using an automated immunohistochemistry staining device. The categorical variables of intensity and coverage were analyzed statistically using Pearson Chi-Square test.
RESULTS
High grade squamous cell lesions cases showed weak (84.4%, n=38/45) to no (15.6%, n=7/45) staining for hCG. None of the HSIL cases showed strong positivity. Strong positivity for hCG was detected in 90.9% (n=50/55) of SCC cases.
CONCLUSION
Our study supports the association of ectopic hCG expression in cancer pathogenesis by demonstrating strong hCG immunoreactivity only in SCC cases. This finding can be helpful in supporting the diagnosis of invasive carcinoma in small or fragmented biopsies, which can on their own be confusing for the pathologists.
目的
比较免疫组化检测鳞状细胞癌（SCC）和高级别鳞状上皮内病变（HSIL）石蜡包埋组织中人绒毛膜促性腺激素（hCG）的表达情况。
方法
本回顾性研究的样本取自土耳其加济安泰普大学加济安泰普病理科2012年1月至2016年9月期间的存档。研究组包括55例SCC和45例HSIL。使用自动免疫组化染色设备通过抗hCG抗体的特异性结合来检测hCG的组织表达。强度和覆盖范围的分类变量采用Pearson卡方检验进行统计学分析。
结果
高级别鳞状细胞病变病例中，hCG染色显示弱阳性（84.4%，n = 38/45）至无染色（15.6%，n = 7/45）。HSIL病例均未显示强阳性。90.9%（n = 50/55）的SCC病例检测到hCG强阳性。
结论
我们的研究通过仅在SCC病例中显示强hCG免疫反应性，支持异位hCG表达与癌症发病机制之间的关联。这一发现有助于支持对小活检或破碎活检中浸润性癌的诊断，而这些活检本身可能会让病理学家感到困惑。
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