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“UW-LPHS 试验”:一种预测腰部疼痛血尿综合征自体肾移植结果的新试验。

The "UW-LPHS Test": A New Test to Predict the Outcome of Renal Autotransplant for Loin Pain Hematuria Syndrome.

作者信息

Sollinger Hans W, Al-Qaoud Talal, Bath Natalie, Redfield Robert R

机构信息

From the Division of Transplantation, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

出版信息

Exp Clin Transplant. 2018 Dec;16(6):651-655. doi: 10.6002/ect.2018.0236. Epub 2018 Sep 25.

DOI:10.6002/ect.2018.0236
PMID:30251941
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6478157/
Abstract

OBJECTIVES

The objectives of this pilot study were twofold. First, we aimed to elicit whether the "UW-LPHS test" definitively localizes pain from patients' loin pain hematuria syndrome to the ureter and thus proves our hypothesis. Second, we aimed to understand whether a positive UW-LPHS test predicts a successful outcome after renal autotransplant.

MATERIALS AND METHODS

The UW-LPHS test is described in detail in this manuscript. Briefly, 0.5% bupivacaine is injected into the ureter of the affected side and kept there using a balloon catheter for 5 minutes.

RESULTS

All six patients studied had complete pain relief at a mean follow-up of 9.2 months after renal autotransplant. All patients were successfully weaned from opioids and have returned to a normal lifestyle.

CONCLUSIONS

The UW-LPHS test can be used to predict renal autotransplant outcomes and should be applied to all patients who are being considered for this operation.

摘要

目的

本初步研究有两个目的。其一,我们旨在确定“UW-LPHS 试验”能否明确将患者腰痛血尿综合征的疼痛定位至输尿管,从而验证我们的假设。其二,我们旨在了解 UW-LPHS 试验结果呈阳性是否预示着自体肾移植术后会有成功的结果。

材料与方法

本文详细描述了 UW-LPHS 试验。简而言之,将 0.5%布比卡因注入患侧输尿管,并使用球囊导管在该处留置 5 分钟。

结果

研究的所有 6 例患者在自体肾移植术后平均 9.2 个月的随访中疼痛完全缓解。所有患者均成功停用阿片类药物,并已恢复正常生活方式。

结论

UW-LPHS 试验可用于预测自体肾移植的结果,应应用于所有考虑进行该手术的患者。

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本文引用的文献

1
Treatment of Nutcracker Syndrome with Open and Endovascular Interventions.
J Vasc Surg Venous Lymphat Disord. 2014 Jan;2(1):116. doi: 10.1016/j.jvsv.2013.10.039. Epub 2013 Dec 12.
2
Does this case hold the answer to one of the worse types of pain in medicine--that of loin pain haematuria syndrome (LPHS).这个病例是否能解答医学上最严重的疼痛类型之一——腰腹痛血尿综合征(LPHS)之谜?
BMJ Case Rep. 2015 Apr 26;2015:bcr2014209165. doi: 10.1136/bcr-2014-209165.
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Loin pain hematuria syndrome.腰痛血尿综合征。
Am J Kidney Dis. 2014 Sep;64(3):460-72. doi: 10.1053/j.ajkd.2014.01.439. Epub 2014 Apr 13.
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[A mini-invasive approach to renal autotransplantation in the management of loin pain hematuria syndrome].[微创方法用于治疗腰部疼痛血尿综合征的自体肾移植]
Prog Urol. 2013 May;23(6):389-93. doi: 10.1016/j.purol.2012.11.010. Epub 2013 Jan 3.
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Ureteric bupivicaine infusion for loin pain haematuria syndrome.输尿管布比卡因灌注治疗腰腹痛血尿综合征。
Ann R Coll Surg Engl. 2010 Mar;92(2):139-41. doi: 10.1308/003588410X12628812458338.
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Loin pain hematuria syndrome: a psychiatric and surgical conundrum.腰痛血尿综合征:一个精神科和外科的难题。
Curr Opin Organ Transplant. 2009 Apr;14(2):186-90. doi: 10.1097/MOT.0b013e32832a2195.
7
Long-term outcomes and late complications of laparoscopic nephrectomy with renal autotransplantation.腹腔镜肾切除术联合自体肾移植的长期预后及晚期并发症
J Urol. 2008 Jan;179(1):240-3. doi: 10.1016/j.juro.2007.08.135. Epub 2007 Nov 14.
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Loin pain hematuria syndrome.
Kidney Int. 2006 Dec;70(12):2152-5. doi: 10.1038/sj.ki.5001946. Epub 2006 Oct 18.
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Proposed pathogenesis of idiopathic loin pain-hematuria syndrome.特发性腰痛-血尿综合征的发病机制假说。
Am J Kidney Dis. 2006 Mar;47(3):419-27. doi: 10.1053/j.ajkd.2005.11.029.
10
Renal autotransplantation for the loin pain-hematuria syndrome: long-term followup of 26 cases.肾自体移植治疗腰腹痛-血尿综合征:26例长期随访
J Urol. 1998 Oct;160(4):1232-5; discussion 1235-6.