Institute of Next Generation Matter Transformation, College of Chemical Engineering , Huaqiao University , 668 Jimei Boulevard , Xiamen , Fujian 361021 , P. R. China.
College of Pharmaceutical Sciences , Zhejiang University of Technology , Hangzhou , 310014 , P.R. China.
Org Lett. 2018 Oct 5;20(19):6161-6165. doi: 10.1021/acs.orglett.8b02629. Epub 2018 Sep 25.
An unprecedented Cu-catalyzed oxidative cleavage of two C-N bonds of 3-aminoindazoles is reported herein, which represents the first example for denitrogenative ring-opening of 3-aminoindazoles. This novel reactivity of 3-aminoindazoles enables the production of diverse aromatic nitrile-containing (hetero)arenes via C-H arylation of (hetero)arenes with wide subsrate scope under mild conditions.
本文报道了一种前所未有的 Cu 催化的 3-氨基吲哚的两个 C-N 键的氧化断裂，这代表了 3-氨基吲哚的首例脱氮开环反应。这种 3-氨基吲哚的新反应性使得通过（杂）芳基与（杂）芳基的 C-H 芳基化，在温和条件下以较宽的底物范围，生成多种含有芳基腈的（杂）芳烃。
