AKR1B10 在肺腺癌切除患者中的预后意义。

Prognostic significance of AKR1B10 in patients with resected lung adenocarcinoma.

机构信息

Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taipei, Taiwan.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.

出版信息

Thorac Cancer. 2018 Nov;9(11):1492-1499. doi: 10.1111/1759-7714.12863. Epub 2018 Sep 25.

DOI:10.1111/1759-7714.12863

PMID:30253058

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6209774/

Abstract

BACKGROUND

Aldo-keto reductases (AKRs) modify carbonyl groups on aldehyde or ketones to form primary or secondary alcohols, which are then conjugated with sulfates or glucuronide for excretion. The AKR1B10 gene encodes a member of the AKR superfamily. Overexpression of AKR1B10 plays an important role in the tumorigenesis of lung cancer cells; however, the prognostic value of AKR1B10 expression in patients with lung adenocarcinoma has not been well demonstrated.

METHODS

A total of 96 patients with resected lung adenocarcinoma were included in the study. AKR1B10 expression was determined by immunohistochemistry in tumor specimens. The prognostic value of AKR1B10 overexpression and its relationship with clinicopathological variables were investigated.

RESULTS

AKR1B10 overexpression was identified in 22 (22.9%) of the 96 patients and tended to be significantly associated with N1 or N2 status (P = 0.055). AKR1B10 overexpression was not a significant prognostic factor for overall survival (P = 0.301) but was a significant prognostic factor for poor recurrence-free survival (P = 0.015). T status (T3 or T4 vs. T1 or T2; P = 0.020), N1 or N2 (vs. N0; P = 0.019), predominant pattern group (lepidic/acinar/papillary vs. micropapillary/solid; P = 0.023), and AKR1B10 overexpression (P = 0.013) were significant prognostic factors for poor recurrence-free survival in multivariate analysis.

CONCLUSIONS

AKR1B10 overexpression was a significant prognostic factor for poor recurrence-free survival in patients with resected lung adenocarcinoma. This information is useful to stratify patients at high-risk of recurrence after lung adenocarcinoma resection.

摘要

背景

醛酮还原酶（AKRs）将醛或酮上的羰基基团修饰为伯醇或仲醇，然后与硫酸盐或葡糖苷酸缀合以排泄。AKR1B10 基因编码 AKR 超家族的成员。AKR1B10 的过表达在肺癌细胞的肿瘤发生中起着重要作用；然而，AKR1B10 表达在肺腺癌患者中的预后价值尚未得到充分证明。

方法

本研究共纳入 96 例接受肺腺癌切除术的患者。通过免疫组织化学法检测肿瘤标本中 AKR1B10 的表达。探讨 AKR1B10 过表达的预后价值及其与临床病理变量的关系。

结果

在 96 例患者中，有 22 例（22.9%）存在 AKR1B10 过表达，且倾向于与 N1 或 N2 状态显著相关（P = 0.055）。AKR1B10 过表达不是总生存期的显著预后因素（P = 0.301），但却是无复发生存率差的显著预后因素（P = 0.015）。T 分期（T3 或 T4 与 T1 或 T2；P = 0.020）、N1 或 N2（与 N0；P = 0.019）、主要形态学分组（贴壁/腺泡/乳头与微乳头/实体；P = 0.023）和 AKR1B10 过表达（P = 0.013）是多因素分析中无复发生存率差的显著预后因素。