肌生成因子和肌融合因子：二者缺一不可。

Myomaker and Myomerger: It Takes Two to Make One.

机构信息

Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H4R2, Canada.

Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H4R2, Canada; Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H4R2, Canada; Department of Pediatrics, Dalhousie University, Halifax, NS B3H4R2, Canada.

出版信息

Dev Cell. 2018 Sep 24;46(6):676-678. doi: 10.1016/j.devcel.2018.09.005.

DOI:10.1016/j.devcel.2018.09.005

PMID:30253167

Abstract

Muscle-forming myotubes are formed from the cell-cell fusion of myoblasts. In this issue of Developmental Cell, Leikina et al. (2018) provide compelling evidence that myoblast fusion is dependent on a two-component membrane fusion complex of Myomaker and Myomerger, which function in hemifusion and pore formation activity, respectively.

摘要

肌管是由成肌细胞的细胞-细胞融合形成的。在本期《发育细胞》中，Leikina 等人（2018 年）提供了令人信服的证据，表明成肌细胞融合依赖于 Myomaker 和 Myomerger 的两成分膜融合复合物，它们分别在半融合和孔形成活性中发挥作用。