Department of Clinical Pharmacology, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark; Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark.
Neurobiology Research Unit, University Hospital of Copenhagen, Rigshospitalet, N9201, 9 Blegdamsvej, DK-2100 Copenhagen, Denmark; Department of Computer Science, University of Copenhagen, Universitetsparken 1, DK-2100 Copenhagen, Denmark.
Int J Psychophysiol. 2018 Dec;134:30-43. doi: 10.1016/j.ijpsycho.2018.09.007. Epub 2018 Sep 22.
In this study we present the test-retest reliability of pre-intervention EEG/ERP (electroencephalogram/event-related potentials) data across four recording intervals separated by a washout period (18-22 days). POz-recording-reference EEG/ERP (28 sites, average reference) were recorded from thirty-two healthy male participants. Participants were randomly allocated into different intervention sequences, each with four intervention regimens: 10 mg vortioxetine, 20 mg vortioxetine, 15 mg escitalopram and Placebo. We report classical EEG spectra: δ (1-4 Hz), θ (4-8 Hz), α (8-12 Hz), β (12-30 Hz), γ1 (30-45 Hz) and γ2 (45-80 Hz) of resting state and vigilance-controlled, and of auditory steady state response, as well as ERP components N100, P200 and P300 in auditory oddball task and error related negativity (ERN) and error positivity (Pe) in hybrid flanker task. Reliability was quantified using intra-class correlation coefficient (ICC). We found that θ, α and β of continuous EEG were highly reliable (ICCs ≥ 0.84). Evoked power of other tasks demonstrated larger variability and less reliability compared to the absolute power of continuous EEG. Furthermore, reliabilities of ERP measures were lower compared to those of the EEG spectra. We saw fair to excellent reliability of the amplitude of the components such as Pe (0.60-0.82) and P300 (0.55-0.80). Moreover, blood tests confirmed that there was no measurable drug carry-over from the previous intervention. The results support that EEG/ERP is reliable across four recording intervals, thus it can be used to assess the effect of different doses and types of drugs with CNS effects.
在这项研究中，我们展示了经过洗脱期（18-22 天）分隔的四个记录间隔的预干预 EEG/ERP（脑电图/事件相关电位）数据的测试-重测信度。从 32 名健康男性参与者中记录了 POz 记录参考 EEG/ERP（28 个部位，平均参考）。参与者被随机分配到不同的干预序列中，每个序列都有四种干预方案：10mg 沃替西汀、20mg 沃替西汀、15mg 依地普仑和安慰剂。我们报告了经典的 EEG 谱：δ（1-4Hz）、θ（4-8Hz）、α（8-12Hz）、β（12-30Hz）、γ1（30-45Hz）和γ2（45-80Hz）的静息状态和警觉控制状态，以及听觉稳态反应，以及听觉Oddball 任务中的 ERP 成分 N100、P200 和 P300，以及混合 Flanker 任务中的错误相关负波（ERN）和错误正波（Pe）。使用组内相关系数（ICC）来量化可靠性。我们发现，连续 EEG 的θ、α和β具有很高的可靠性（ICC≥0.84）。与连续 EEG 的绝对功率相比，其他任务的诱发功率具有更大的可变性和更低的可靠性。此外，与 EEG 谱相比，ERP 测量的可靠性较低。我们发现 Pe（0.60-0.82）和 P300（0.55-0.80）等成分的振幅具有良好到优秀的可靠性。此外，血液测试证实，先前干预的药物残留量可测量。结果支持 EEG/ERP 在四个记录间隔内具有可靠性，因此可以用于评估具有中枢神经系统作用的不同剂量和类型药物的效果。
