Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand.
Ocul Surf. 2019 Jan;17(1):83-88. doi: 10.1016/j.jtos.2018.09.005. Epub 2018 Sep 22.
To investigate the ethnic differences in tear film quality, ocular surface parameters, and dry eye symptomology between co-located Asian and Caucasian populations.
Two hundred and six participants (103 East Asian and 103 Caucasian) were recruited in an age and gender-matched cross-sectional study. Dry eye symptomology, ocular surface parameters, and tear film quality were evaluated for each participant within a single clinical session.
The mean ± SD age of the 206 participants (82 male, 124 female) was 45 ± 16 years. Overall, a greater proportion of Asian participants were symptomatic of dry eye and fulfilled the TFOS DEWS II dry eye diagnostic criteria than Caucasian participants (74% versus 51%, p = 0.002), with an odds ratio (95% CI) of 2.7 (1.5-4.8) times. Poorer OSDI scores, tear film stability, lipid layer quality, tear osmolarity, lid wiper epitheliopathy, meibomian gland dropout, and expressed meibum quality were observed in the Asian group (all p < 0.05). A significantly higher proportion of participants exhibited incomplete blinking in the Asian group than the Caucasian group (81% versus 45%, p < 0.001).
Asian participants exhibited more severe dry eye signs and symptoms than Caucasian participants. The poorer meibomian gland function and higher degree of incomplete blinking observed among Asian participants may potentially contribute towards the ethnic predisposition towards dry eye development.
调查亚洲和高加索人群的泪膜质量、眼表参数和干眼症状学的种族差异。
在一项年龄和性别匹配的横断面研究中，共招募了 206 名参与者（103 名东亚人和 103 名高加索人）。在单个临床检查中，对每位参与者的干眼症状、眼表参数和泪膜质量进行评估。
206 名参与者（82 名男性，124 名女性）的平均年龄为 45 ± 16 岁。总体而言，与高加索参与者相比，更多的亚洲参与者存在干眼症状并符合 TFOS DEWS II 干眼诊断标准（74%对 51%，p = 0.002），优势比（95%可信区间）为 2.7（1.5-4.8）倍。亚洲组的 OSDI 评分、泪膜稳定性、脂质层质量、泪液渗透压、睑板腺上皮病变、睑板腺缺失和表达的睑脂质量均较差（均 p < 0.05）。与高加索组相比，亚洲组参与者不完全眨眼的比例显著更高（81%对 45%，p < 0.001）。
亚洲参与者的干眼体征和症状比高加索参与者更严重。亚洲参与者的睑板腺功能较差和不完全眨眼程度较高，可能有助于解释其对干眼发展的种族易感性。
