Lum Jarrad A G, Mills Andrea, Plumridge James M A, Sloan Nicole P, Clark Gillian M, Hedenius Martina, Enticott Peter G
Deakin University, Geelong, Australia, Cognitive Neuroscience Unit, School of Psychology, Australia.
Deakin University, Geelong, Australia, Cognitive Neuroscience Unit, School of Psychology, Australia.
Brain Cogn. 2018 Nov;127:34-41. doi: 10.1016/j.bandc.2018.09.006. Epub 2018 Sep 22.
This study examined the role of the left inferior frontal gyrus in the implicit learning and retention of a 'simple' first order conditional (FOC) sequence and a relatively 'complex' second order conditional (SOC) sequence, using anodal transcranial direct current stimulation (a-tDCS). Groups of healthy adults received either a-tDCS (n = 18) over the left inferior frontal gyrus or sham/placebo (n = 18) stimulation. On separate days, participants completed a serial reaction time (SRT) task whilst receiving stimulation. On one of the days, participants were presented with a FOC sequence and in another, a SOC sequence. Both the learning and short-term retention of the sequences were measured. Results showed a-tDCS enhanced the short-term retention of the SOC sequence but not the FOC sequence. There was no effect of a-tDCS on the learning of either FOC or SOC sequences. The results provide evidence of prefrontal involvement in the retention of a motor sequence. However, its role appears to be influenced by the complexity of the sequence's structure. Additionally, the results show a-tDCS can enhance retention of an implicitly learnt motor sequence.
本研究使用阳极经颅直流电刺激（a-tDCS），考察了左侧额下回在“简单”的一阶条件（FOC）序列和相对“复杂”的二阶条件（SOC）序列的内隐学习及记忆保持中的作用。健康成年人群体中，一部分（n = 18）接受左侧额下回的a-tDCS刺激，另一部分（n = 18）接受假刺激/安慰剂刺激。在不同日期，参与者在接受刺激的同时完成序列反应时（SRT）任务。其中一天，向参与者呈现FOC序列，另一天呈现SOC序列。对序列的学习和短期记忆保持情况均进行了测量。结果显示，a-tDCS增强了SOC序列的短期记忆保持，但未增强FOC序列的短期记忆保持。a-tDCS对FOC序列或SOC序列的学习均无影响。研究结果为前额叶参与运动序列的记忆保持提供了证据。然而，其作用似乎受序列结构复杂性的影响。此外，结果表明a-tDCS可增强内隐学习的运动序列的记忆保持。
