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床旁粘弹性检测设备(旋转血栓弹力测定法和血栓弹力图):外科医生入门指南

Point-of-care viscoelastic assay devices (rotational thromboelastometry and thromboelastography): a primer for surgeons.

作者信息

Sharp Gary, Young Christopher J

机构信息

Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

Discipline of Surgery, The University of Sydney, Sydney, New South Wales, Australia.

出版信息

ANZ J Surg. 2019 Apr;89(4):291-295. doi: 10.1111/ans.14836. Epub 2018 Sep 25.

Abstract

BACKGROUND

Bleeding is a common occurrence in surgery. Point-of-care testing with viscoelastic (VE) assays such as thromboelastography (TEG) and rotational thromboelastometry (ROTEM) has become more common place. TEG and ROTEM have the potential to guide management of coagulopathy. Many healthcare professionals still rely upon standard laboratory tests (SLTs) to manage a bleeding patient. It was our aim to investigate the literature surrounding management of the surgically bleeding patient via VE assays.

METHODS

Literature review of Embase, MEDLINE, PubMed and the Cochrane Library using 'TEG, ROTEM and surgery' search terms was conducted.

RESULTS

Through the literature search and reference lists reviewed by both authors, a total of 62 articles have been evaluated, 35 of these have been included in this review.

CONCLUSION

VE assays are used most commonly during orthotopic liver transplantation, trauma, postpartum haemorrhage and cardiac surgery. Although the evidence is not overwhelming, we have identified recurrent themes where VE assays seem to be beneficial. VE assay use, especially when incorporated into an algorithm, appears to reduce blood product administration which in turn reduces cost and potential adverse events. They are quicker than SLTs and they can detect hyperfibrinolysis, the hallmark of coagulopathy, via in vivo clot analyses which SLTs are unable to do. Ultimately more randomized controlled trials are required.

摘要

背景

出血是手术中常见的情况。使用诸如血栓弹力图(TEG)和旋转血栓弹力测定法(ROTEM)等粘弹性(VE)检测进行床旁检测已变得更加普遍。TEG和ROTEM有指导凝血病管理的潜力。许多医疗保健专业人员仍依赖标准实验室检测(SLTs)来处理出血患者。我们的目的是研究通过VE检测对手术出血患者进行管理的相关文献。

方法

使用“TEG、ROTEM和手术”搜索词对Embase、MEDLINE、PubMed和Cochrane图书馆进行文献综述。

结果

通过文献检索以及两位作者审查的参考文献列表,共评估了62篇文章,其中35篇已纳入本综述。

结论

VE检测最常用于原位肝移植、创伤、产后出血和心脏手术。尽管证据并不充分,但我们已确定了VE检测似乎有益的反复出现的主题。使用VE检测,尤其是将其纳入算法时,似乎可减少血液制品的使用,进而降低成本和潜在不良事件。它们比SLTs更快,并且可以通过体内凝块分析检测纤溶亢进,这是凝血病的标志,而SLTs无法做到这一点。最终,需要更多的随机对照试验。

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