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皮肤结节病与复发性转移性乳腺癌的并发诊断:仅仅是巧合吗?

Concurrent Diagnoses of Cutaneous Sarcoidosis and Recurrent Metastatic Breast Cancer: More than a Coincidental Occurrence?

作者信息

Deen Jacqueline, Mellick Nick, Wheller Laura

机构信息

Department of Dermatology, Sunshine Coast University Hospital, 6 Doherty Street, Birtinya, Queensland 4575, Australia.

Department of Pathology, Medlab Pathology, 280 Newmarket Road, Wilston, Queenslan 4051, Australia.

出版信息

Case Rep Dermatol Med. 2018 Sep 5;2018:2812439. doi: 10.1155/2018/2812439. eCollection 2018.

Abstract

Sarcoidosis is a rare, chronic, multisystem disease of unknown aetiology, characterised by non-caseating epithelioid cell granulomas. Its association with internal malignancy, in particular haematological cancers has been strongly documented in the literature, while its link with solid organ malignancies is less extensively reported. We present an atypical case of cutaneous sarcoidosis occurring in association with breast cancer recurrence in a 49-year-old female. Physician recognition of this link between sarcoidosis and internal malignancy is vital because many cases of sarcoidosis in association with neoplasia present initially, or even exclusively, with cutaneous sarcoidal lesions that may precede the development of cancer by several years, or as in our case, present as a cutaneous marker of concomitant underlying malignancy. Our case highlights the importance of age-appropriate cancer screening in additional to a routine work-up for systemic sarcoidosis in a patient with cutaneous sarcoidosis.

摘要

结节病是一种病因不明的罕见慢性多系统疾病,其特征为非干酪样上皮样细胞肉芽肿。文献中已有力证明其与内部恶性肿瘤,尤其是血液系统癌症有关,而其与实体器官恶性肿瘤的联系报道较少。我们报告一例49岁女性皮肤结节病合并乳腺癌复发的非典型病例。医生认识到结节病与内部恶性肿瘤之间的这种联系至关重要,因为许多结节病合并肿瘤的病例最初甚至仅表现为皮肤结节样病变,这些病变可能在癌症发生前数年出现,或者如我们的病例所示,表现为伴随潜在恶性肿瘤的皮肤标志物。我们的病例强调了在对皮肤结节病患者进行系统性结节病常规检查的同时,进行适龄癌症筛查的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a34b/6145152/2231eed93ffe/CRIDM2018-2812439.001.jpg

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