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II型糖尿病患者胰岛细胞的再生

Regeneration of Pancreatic -Islet Cells in a Type-II Diabetic.

作者信息

Jones Edwin C, Rylands J Craig, Jardet Cortney L

机构信息

Department of Veterans Affairs, Knoxville Outpatient Clinic, 8033 Ray Mears Blvd., Knoxville, TN 37919, USA.

Summit Medical Group, 7211 Wellington Dr. #201, Knoxville, TN 37919, USA.

出版信息

Case Rep Endocrinol. 2018 Sep 5;2018:6147349. doi: 10.1155/2018/6147349. eCollection 2018.

Abstract

A case report is presented in which a type-II diabetic patient significantly improved his dysfunctional -islet cells using a combination of a strenuous exercise program, cyclical ketogenic diet, and oral GABA/probiotic supplementation. The patient was diagnosed with type-II diabetes at the age of 41 which then progressed through a typical series of treatment changes over 14 years. Treatment periods consisted of metformin therapy alone for 4 years followed by a metformin/glyburide combination therapy for 6 years, and eventually an insulin/metformin combination therapy for 4 years. One year after the initiation of insulin, the patient increased the level of strenuous physical activity (hiking and weight lifting) and adopted a ketogenic diet. Oral GABA and probiotic supplementation were also initiated at the age of 52.7. By the age of 55, the patient no longer required any insulin and is currently being managed with metformin alone. C-peptide values indicate a functional improvement of the -islet cells during the time of insulin/GABA/probiotic treatment.

摘要

本文报告了一例II型糖尿病患者的病例,该患者通过高强度运动计划、周期性生酮饮食以及口服GABA/益生菌补充剂的联合使用,显著改善了其功能失调的胰岛细胞。该患者在41岁时被诊断为II型糖尿病,随后在14年中经历了一系列典型的治疗变化。治疗阶段包括单独使用二甲双胍治疗4年,随后二甲双胍/格列本脲联合治疗6年,最终胰岛素/二甲双胍联合治疗4年。开始使用胰岛素一年后,患者增加了高强度体育活动(徒步旅行和举重)的水平,并采用了生酮饮食。口服GABA和益生菌补充剂也在52.7岁时开始使用。到55岁时,患者不再需要任何胰岛素,目前仅用二甲双胍进行治疗。C肽值表明在胰岛素/GABA/益生菌治疗期间胰岛细胞的功能有所改善。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0fc/6145154/10914d5d5565/CRIE2018-6147349.001.jpg

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